{"id":"W2018976354","doi":"10.1038/mp.2013.19","title":"APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study","year":2013,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; University of California, San Diego; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; University of California, Los Angeles; Ipsen; U.S. Food and Drug Administration; Servier; Eisai; Bayer HealthCare; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Medpace; Elan; Novartis; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Alzheimer's Association; Amorfix Life Sciences; Synarc; TauRx Pharmaceuticals; National Science Foundation","keywords":"Genome-wide association study; Apolipoprotein E; Pittsburgh compound B; Genetic association; Alzheimer's disease; Temporal cortex; Butyrylcholinesterase; Neuroimaging; Locus (genetics); Neuroscience; Medicine; Genetics; Biology; Internal medicine; Psychology; Disease; Single-nucleotide polymorphism; Gene; Acetylcholinesterase; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021448,0.001053451,0.0007408331,0.0007504216,0.0009112839,0.0009407179,0.000677049,0.001274743,0.001987812],"category_scores_gemma":[0.00126854,0.0007297867,0.001094151,0.001191885,0.0005857992,0.0005072337,0.0005697545,0.0009854157,0.0002253753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003149888,"about_ca_system_score_gemma":0.000282699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009658716,"about_ca_topic_score_gemma":0.009399655,"domain_scores_codex":[0.9995618,0.0001356881,0.00003963662,0.0001493818,0.00005469974,0.000058717],"domain_scores_gemma":[0.9993023,0.0002857093,0.0001370049,0.0001061174,0.00006381003,0.0001050647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01042506,0.0005251209,0.9502236,0.00008197204,0.003862043,0.003321569,0.0007353441,0.0002839929,0.02426965,0.0003126518,0.0002696705,0.005689323],"study_design_scores_gemma":[0.0001513108,0.0002498889,0.995499,0.000007305036,0.001395119,0.001109079,0.0001736583,0.0004594092,0.000526153,0.000134254,0.000280537,0.00001424371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989094,0.0004628555,0.0001877058,0.00006328053,0.0000068404,0.000005647543,0.0001120084,0.000005824371,0.0002464778],"genre_scores_gemma":[0.999217,0.0001476745,0.0002077542,0.00003371294,0.00001240224,0.000004523148,0.00008530289,0.000005870181,0.0002857982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009658716,"threshold_uncertainty_score":0.01920503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0068775382134073,"score_gpt":0.2613882336363157,"score_spread":0.2545106954229084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}