{"id":"W2018983895","doi":"10.1016/j.immuni.2010.02.012","title":"Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases","year":2010,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":510,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia; McGill University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; McGill University Health Centre","keywords":"Azoxymethane; Inflammasome; Colitis; Inflammation; Caspase; Cancer research; Biology; Colorectal cancer; Apoptosis; Cancer; Immune system; Intestinal mucosa; Immunology; Programmed cell death; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004030783,0.0003613721,0.0002966153,0.0004946638,0.00020621,0.0007530205,0.0002159958,0.0003276802,0.0009866444],"category_scores_gemma":[0.0004503782,0.0001058147,0.0002290605,0.0002586618,0.0006659857,0.0006539963,0.000481588,0.0007207165,0.000221538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000463094,"about_ca_system_score_gemma":0.0002733164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001609879,"about_ca_topic_score_gemma":0.0002602976,"domain_scores_codex":[0.9997488,0.00007572163,0.00002747555,0.0000458332,0.00005013421,0.00005198254],"domain_scores_gemma":[0.99968,0.0000257884,0.0001544185,0.00003069835,0.0000324904,0.00007654395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004060736,0.0001783621,0.006796318,0.0006842427,0.00006513985,0.001030645,0.0001744004,0.0009819034,0.9061058,0.01601122,0.001756431,0.06215478],"study_design_scores_gemma":[0.0008876615,0.001945151,0.08081611,0.0002595512,0.0001531669,0.009978291,0.0007447479,0.005451995,0.8015184,0.03288741,0.06525262,0.0001049162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8268543,0.1453992,0.0123118,0.005681655,0.0004661268,0.00004937456,0.0006755023,0.0002521189,0.008309949],"genre_scores_gemma":[0.9749849,0.01946092,0.002782275,0.0002398196,0.0000938002,0.00001979268,0.0001714104,0.00002025931,0.002226767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009866444,"threshold_uncertainty_score":0.003360033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004571074976026062,"score_gpt":0.2279315943475893,"score_spread":0.2233605193715633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}