{"id":"W2018983895","doi":"10.1016/j.immuni.2010.02.012","title":"Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases","year":2010,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":510,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia; McGill University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; McGill University Health Centre","keywords":"Azoxymethane; Inflammasome; Colitis; Inflammation; Caspase; Cancer research; Biology; Colorectal cancer; Apoptosis; Cancer; Immune system; Intestinal mucosa; Immunology; Programmed cell death; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829776,0.000133319,0.0001617301,0.00001941118,0.0001903472,0.00002059014,0.0002091498,0.0001392097,0.00004701469],"category_scores_gemma":[0.0003686567,0.0001109799,0.00005713221,0.00006112405,0.0004463826,0.000005950544,0.00009846882,0.0002726879,0.000001411299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001004392,"about_ca_system_score_gemma":0.0001379028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002264514,"about_ca_topic_score_gemma":0.003973867,"domain_scores_codex":[0.9991966,0.0001518704,0.000207324,0.0001288021,0.0000885066,0.0002268244],"domain_scores_gemma":[0.9993342,0.00007111639,0.0001398572,0.0002331344,0.0001783198,0.00004332661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003787978,0.00009368784,0.03920235,0.00001875655,0.0001468557,0.0000015002,0.000158219,0.000001686682,0.9542143,0.0001269845,0.002147413,0.003509384],"study_design_scores_gemma":[0.001742698,0.0003136007,0.4612352,0.00002434879,0.0000517519,0.00002457415,0.000480208,0.00002659635,0.5219924,0.00005432351,0.01382962,0.0002247104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966504,0.002248658,0.00001005124,0.0001271471,0.0001465139,0.0002277065,0.0002559986,0.000009679384,0.0003238294],"genre_scores_gemma":[0.9991701,0.0003311069,0.000006970316,0.0001529015,0.00003494217,0.00005621157,0.0001478823,0.00001424628,0.00008564827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.432222,"threshold_uncertainty_score":0.452563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004571074976026062,"score_gpt":0.2279315943475893,"score_spread":0.2233605193715633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}