{"id":"W2018987043","doi":"10.1074/jbc.m111.270751","title":"Inhibitory Member of the Apoptosis-stimulating Proteins of the p53 Family (iASPP) Interacts with Protein Phosphatase 1 via a Noncanonical Binding Motif","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wellcome Trust; Ludwig Institute for Cancer Research; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Pfizer; Eli Lilly and Company","keywords":"Phosphatase; Protein phosphatase 1; SH3 domain; Biology; Cell biology; Plasma protein binding; WW domain; Proto-oncogene tyrosine-protein kinase Src; Signal transduction; Molecular biology; Phosphorylation; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003873387,0.0001984192,0.0004776486,0.00002483137,0.00005534207,0.000005545432,0.0003512923,0.0002540312,0.0001175533],"category_scores_gemma":[0.0006036626,0.00008921287,0.0003415309,0.0002626315,0.0003861455,0.00004567892,0.0001810623,0.0009354859,0.000001061354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285519,"about_ca_system_score_gemma":0.0003384722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001970379,"about_ca_topic_score_gemma":8.230863e-7,"domain_scores_codex":[0.9982943,0.00008365184,0.0007612245,0.0001896149,0.0004420285,0.0002291777],"domain_scores_gemma":[0.9980426,0.00006424185,0.001114748,0.0003712787,0.0002725621,0.0001345546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008249715,0.0003150014,0.003423155,0.0001538344,0.0001317357,0.00002735154,0.000152155,0.00002859981,0.9943717,0.000004185782,0.00003866457,0.0005286793],"study_design_scores_gemma":[0.001440273,0.0006195818,0.004458671,0.001887919,0.0001157849,0.0002122645,0.0001427422,0.0000408093,0.9908804,0.00002288681,0.00007506322,0.0001035653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975449,0.0003210571,0.0001548325,0.0001140337,0.00008862343,0.0004731558,0.00001716909,0.000008317564,0.001277869],"genre_scores_gemma":[0.9982249,0.000006380049,0.001494915,0.00007276332,0.0001224672,0.00001160059,0.000002319463,0.00001727158,0.00004739973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491228,"threshold_uncertainty_score":0.4064273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746961092906845,"score_gpt":0.2462425264764987,"score_spread":0.2087729155474302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}