{"id":"W2018998862","doi":"10.1038/cr.2014.29","title":"Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila","year":2014,"lang":"en","type":"article","venue":"Cell Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Chinese Academy of Sciences; Institute of Genetics; National Institute of General Medical Sciences; National Natural Science Foundation of China","keywords":"Hedgehog; Downregulation and upregulation; Biology; Hedgehog signaling pathway; Ubiquitin ligase; Signal transduction; RNA interference; Cell biology; Suppressor; Ubiquitin; Genetics; Regulator; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001894242,0.0001802797,0.000259957,0.00009816369,0.0002016496,0.00003491102,0.0006388539,0.0001850691,0.00003991538],"category_scores_gemma":[0.0005809517,0.000134116,0.0001117952,0.0003612729,0.0007765565,0.000005317171,0.0004357209,0.000342736,0.00003300341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002303466,"about_ca_system_score_gemma":0.00009510791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000181908,"about_ca_topic_score_gemma":0.00006945346,"domain_scores_codex":[0.9975075,0.0005730629,0.0003546577,0.0004754303,0.0004754836,0.0006139007],"domain_scores_gemma":[0.998444,0.0003882131,0.00007286728,0.00072389,0.0003046795,0.00006637352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009685721,0.00009673041,0.0009301498,0.00009489224,0.00002534322,0.00000315432,0.0009355446,0.0004823027,0.9952132,0.000235707,0.001377313,0.0005088518],"study_design_scores_gemma":[0.0006367056,0.0002882785,0.0008867151,0.00004595713,0.000006147022,0.000001409694,0.0007170452,0.0001612297,0.9800477,0.00102,0.01603498,0.0001538445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893192,0.002180243,0.0001630862,0.0006363071,0.00007957748,0.0003502742,0.00001221293,0.00001106743,0.007248054],"genre_scores_gemma":[0.9980563,0.0001781821,0.0002487238,0.00006672444,0.0002573077,0.0000510337,0.00002778023,0.00003591951,0.001078016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01516546,"threshold_uncertainty_score":0.546909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0548103615181513,"score_gpt":0.3355121509207781,"score_spread":0.2807017894026268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}