{"id":"W2019017258","doi":"10.3390/ph3030636","title":"Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides","year":2010,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Guanidine; Dendrimer; Conjugate; Combinatorial chemistry; Conjugated system; Cell-penetrating peptide; Chemistry; Cell; Peptide; Intracellular; Biophysics; Nanotechnology; Materials science; Biochemistry; Biology; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002746046,0.0003828374,0.0008069267,0.0001015624,0.0000555994,0.00003243242,0.0004642098,0.0003952066,0.0001298001],"category_scores_gemma":[0.0001531844,0.0003178151,0.0005090971,0.0001195506,0.000144678,0.000002188255,0.0001958175,0.0003602937,0.0001594241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000949376,"about_ca_system_score_gemma":0.0002022666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000076976,"about_ca_topic_score_gemma":0.000004090527,"domain_scores_codex":[0.9981919,0.0001387569,0.0006361143,0.0004969204,0.0001872982,0.0003490266],"domain_scores_gemma":[0.9989364,0.00008596081,0.0002685929,0.0004185638,0.0001437558,0.0001466836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002944419,0.0003813322,0.00003024018,0.01269165,0.0003168794,0.00003067514,0.00004417189,0.00001442127,0.5045664,0.00009878628,0.00125008,0.4805459],"study_design_scores_gemma":[0.000144923,0.0001539977,0.000001420081,0.001194373,0.0005394337,0.00005464286,0.00002436012,0.00001681643,0.1635364,0.00001065503,0.8339534,0.0003695718],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01759672,0.9782506,0.00003267144,0.00000715413,0.0002977976,0.0003511181,0.00007371505,0.00001185788,0.003378395],"genre_scores_gemma":[0.03425928,0.9642623,0.0002438102,0.00008736987,0.0003848866,0.00004500983,0.0002126955,0.00004606897,0.0004585766],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8327034,"threshold_uncertainty_score":0.9999274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06299257684758826,"score_gpt":0.396247186171956,"score_spread":0.3332546093243677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}