{"id":"W2019019161","doi":"10.1007/s12015-012-9356-9","title":"Hematopoietic MyD88-adaptor Protein Acts as a Natural Defense Mechanism for Cognitive Deficits in Alzheimer’s Disease","year":2012,"lang":"en","type":"article","venue":"Stem Cell Reviews and Reports","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Signal transducing adaptor protein; Microglia; Cell biology; Biology; Innate immune system; Receptor; Haematopoiesis; Immunology; Amyloid precursor protein; Stem cell; Alzheimer's disease; Neuroscience; Immune system; Signal transduction; Medicine; Disease; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005622298,0.0002762789,0.0003758634,0.0001019006,0.0001850569,0.00007281848,0.00006903229,0.00005933675,0.00002228263],"category_scores_gemma":[0.0004255731,0.0002166145,0.0001354284,0.0001828898,0.00003451511,0.0002939631,0.00005889264,0.0001504161,0.0000425074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001428479,"about_ca_system_score_gemma":0.00006514221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001405476,"about_ca_topic_score_gemma":0.000002202784,"domain_scores_codex":[0.9977137,0.0002878158,0.000731495,0.0005776779,0.0002763907,0.0004129622],"domain_scores_gemma":[0.9987167,0.0001249322,0.000486009,0.0002754237,0.0000604509,0.0003365104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008134307,0.0002037981,0.00005440272,0.0004453294,0.00000341128,0.0003570438,0.0003965042,7.020553e-7,0.9549439,0.04055306,0.00008745901,0.002873071],"study_design_scores_gemma":[0.0004027915,0.00008102091,0.00004227934,0.0002723019,0.00007542685,0.0003502842,0.00004651977,0.0000978868,0.9882331,0.001724378,0.008335432,0.0003385943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794021,0.01142818,0.0005685,0.0002558685,0.0009361266,0.006277893,0.00001463777,0.00008985077,0.001026889],"genre_scores_gemma":[0.995956,0.0009121301,0.0001633044,0.001106752,0.00008068691,0.0006188761,0.000009369454,0.00003694445,0.001115942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03882868,"threshold_uncertainty_score":0.8833283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05656310181288555,"score_gpt":0.2889519777627849,"score_spread":0.2323888759498993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}