{"id":"W2019039109","doi":"10.1038/nature09337","title":"A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":420,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Cancer Research Institute; York University; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; Howard Hughes Medical Institute","keywords":"Innate immune system; Dendritic cell; Biology; Cyclophilin A; Cypa; Cell biology; Immune system; Acquired immune system; Interferon; Virology; Infectivity; Capsid; Immunology; Virus; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002968085,0.0003015608,0.0003142264,0.0002088046,0.0004148301,0.001156569,0.000415219,0.0008313484,0.003485163],"category_scores_gemma":[0.0002693576,0.0002038131,0.0003342257,0.0001488057,0.0003458833,0.0009238071,0.0009052257,0.001514535,0.001173639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008617308,"about_ca_system_score_gemma":0.0003936739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001011735,"about_ca_topic_score_gemma":0.0001680596,"domain_scores_codex":[0.9997361,0.00002693186,0.000009677005,0.00006231143,0.00006556585,0.00009941341],"domain_scores_gemma":[0.9998579,0.00001642748,0.00002551591,0.00002374626,0.00002072942,0.00005560935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000308277,0.00002616601,0.0003184683,0.00004970634,0.000007733987,0.0001428445,0.00002663234,0.0001250306,0.9936422,0.00205444,0.00039763,0.002900867],"study_design_scores_gemma":[0.0001039095,0.00031252,0.003935136,0.00002611393,0.00001758328,0.0009465354,0.0001631786,0.002778444,0.9783096,0.003259956,0.01012813,0.0000188072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735227,0.005562456,0.009406647,0.00189251,0.0006070058,0.00007580666,0.0006119956,0.0001918129,0.008129152],"genre_scores_gemma":[0.9929596,0.0009345108,0.002520302,0.000424224,0.00008088222,0.00001808986,0.000310963,0.00002205136,0.002729334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003485163,"threshold_uncertainty_score":0.01165909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007774086880029227,"score_gpt":0.2721489239425894,"score_spread":0.2643748370625602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}