{"id":"W2019150978","doi":"10.1124/dmd.107.018192","title":"Effects of Chronic Renal Failure on Liver Drug Transporters","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Drug; Pharmacology; Transporter; Chronic renal failure; Drug metabolism; Medicine; Pharmacokinetics; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002468798,0.0001826768,0.0003506044,0.000161327,0.00007179257,0.000007240495,0.00004817105,0.00007717036,0.00003430521],"category_scores_gemma":[0.000003248354,0.0001425255,0.0001410647,0.0001580985,0.00008283021,0.0001003117,0.000003950133,0.0001530448,0.000006825667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002339834,"about_ca_system_score_gemma":0.00003131094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000364362,"about_ca_topic_score_gemma":0.00009337773,"domain_scores_codex":[0.9989055,0.00002158163,0.0002630889,0.0002546232,0.0003015415,0.0002536653],"domain_scores_gemma":[0.9995138,0.00004525352,0.00007959661,0.0001499952,0.00004439509,0.0001669659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002560963,0.001003272,0.0004603497,0.002353027,0.0001943909,0.0006146682,0.003945577,0.00001144221,0.9233456,0.02237067,0.0006765446,0.04246348],"study_design_scores_gemma":[0.00401908,0.0001373601,0.3186059,0.0006439852,0.0008078821,0.00001974808,0.0001989917,0.00003483236,0.6690693,0.0002349739,0.005986775,0.0002411126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889327,0.004677108,0.004736015,0.0002872807,0.000204263,0.0004414215,0.00001788808,0.00005003217,0.0006533248],"genre_scores_gemma":[0.9979017,0.0005202969,0.0004493014,0.0002049908,0.0002638029,0.000009193444,0.0001045675,0.00002116287,0.0005249902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3181455,"threshold_uncertainty_score":0.581202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002809008277781428,"score_gpt":0.2038395831473487,"score_spread":0.2010305748695673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}