{"id":"W2019150978","doi":"10.1124/dmd.107.018192","title":"Effects of Chronic Renal Failure on Liver Drug Transporters","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Drug; Pharmacology; Transporter; Chronic renal failure; Drug metabolism; Medicine; Pharmacokinetics; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007120058,0.0003672764,0.001113862,0.000191395,0.0004954335,0.0007131732,0.0002207153,0.0006012755,0.003788271],"category_scores_gemma":[0.001615785,0.0001580509,0.0008587664,0.000263693,0.000574801,0.0006422119,0.0004145121,0.0009276491,0.0002455787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006379274,"about_ca_system_score_gemma":0.0006947689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003931038,"about_ca_topic_score_gemma":0.003869555,"domain_scores_codex":[0.9996668,0.0001353462,0.00002235153,0.00002362292,0.00003609304,0.0001156862],"domain_scores_gemma":[0.9981805,0.0008217729,0.0001864334,0.0001694707,0.000181228,0.0004605852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3889348,0.002428934,0.2187757,0.001023151,0.002178248,0.007548346,0.0008447929,0.0035795,0.2554504,0.002265441,0.001953994,0.1150167],"study_design_scores_gemma":[0.003072833,0.02426931,0.9090021,0.0001081748,0.001482768,0.003706504,0.0007523691,0.002869531,0.04557156,0.00110694,0.007982837,0.00007499642],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943982,0.003404793,0.0001476786,0.0003536627,0.00003796261,0.00001393162,0.000170472,0.0000132562,0.001460132],"genre_scores_gemma":[0.9981297,0.0007395593,0.0001053903,0.0001264598,0.00004508388,0.000006135564,0.0001090355,0.000008124332,0.000730523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003931038,"threshold_uncertainty_score":0.01267302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002809008277781428,"score_gpt":0.2038395831473487,"score_spread":0.2010305748695673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}