{"id":"W2019177531","doi":"10.1210/en.2004-1317","title":"Gonadotropin-Releasing Hormone Pulse Frequency-Dependent Activation of Extracellular Signal-Regulated Kinase Pathways in Perifused LβT2 Cells","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"MAPK/ERK pathway; Internal medicine; Endocrinology; Stimulation; Extracellular; Kinase; Biology; Gonadotropin-releasing hormone; Phosphorylation; Chemistry; Luteinizing hormone; Hormone; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001513464,0.0003184783,0.0007195316,0.0004968641,0.00005269287,0.000009419538,0.0001794723,0.0001839426,0.0003150955],"category_scores_gemma":[0.0001998321,0.0003163821,0.0001418479,0.0002752781,0.0002031033,0.0002064778,0.0000669129,0.0005016867,0.00007491146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003431443,"about_ca_system_score_gemma":0.0001806677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003310337,"about_ca_topic_score_gemma":0.00002790513,"domain_scores_codex":[0.9973851,0.0001916153,0.000742697,0.0006633209,0.0003465241,0.0006707103],"domain_scores_gemma":[0.9986197,0.0001166741,0.0002754999,0.0006491494,0.0002214065,0.0001175438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004737664,0.0005247759,0.003024128,0.00004031806,0.00008148809,0.0003039126,0.0003846094,0.0002904065,0.95864,0.0008636587,0.00003442852,0.03533846],"study_design_scores_gemma":[0.00538826,0.0005725354,0.1826745,0.00006793658,0.00008325345,0.000212221,0.0001881585,0.0007051312,0.808408,0.0002582411,0.001158636,0.0002832146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886871,0.006967135,0.0007035194,0.0020859,0.0001191574,0.000783923,0.000009585228,0.0001083996,0.0005352539],"genre_scores_gemma":[0.9956027,0.0003201429,0.003167953,0.0000795343,0.0002536761,0.00004521036,0.00002632418,0.00005316406,0.0004512913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1796503,"threshold_uncertainty_score":0.9999288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01847178895276825,"score_gpt":0.2407474204389558,"score_spread":0.2222756314861875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}