{"id":"W2019211685","doi":"10.1016/j.bbadis.2015.01.006","title":"The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Major State Basic Research Development Program of China; Cardinal Tien Hospital; Fu Jen Catholic University; Ministry of Science and Technology, Taiwan; National Natural Science Foundation of China","keywords":"AMPK; Metformin; Neuroprotection; TFAM; Mitochondrial biogenesis; AMP-activated protein kinase; Biology; Neural stem cell; Mitochondrion; NRF1; Protein kinase A; Cell biology; Endocrinology; Pharmacology; Kinase; Stem cell; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001520394,0.0002580337,0.0002756068,0.0002625826,0.0002162806,0.000320389,0.0001661108,0.0003003634,0.001749914],"category_scores_gemma":[0.00009161203,0.0001138598,0.0003913379,0.0001537718,0.0001971491,0.0002711564,0.000152387,0.0007175633,0.0002443698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002232496,"about_ca_system_score_gemma":0.0003434396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005504143,"about_ca_topic_score_gemma":0.001139214,"domain_scores_codex":[0.9999093,0.00001385096,0.00001275957,0.00001462652,0.00001992098,0.00002952722],"domain_scores_gemma":[0.9999386,0.000009111817,0.00001500435,0.000009405173,0.0000120986,0.00001583414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001563298,0.0002227066,0.0006880623,0.0001317523,0.00005279505,0.0002521708,0.00003953202,0.0001237522,0.9898546,0.0006922689,0.0002634647,0.006115675],"study_design_scores_gemma":[0.0001330027,0.00109552,0.01297666,0.00002078634,0.00009425035,0.0003036444,0.0001121087,0.0004765133,0.9808295,0.0003071604,0.003642506,0.000008392963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926215,0.003559103,0.0009087456,0.0003217443,0.0001653911,0.00002108496,0.0005160064,0.00003187858,0.001854448],"genre_scores_gemma":[0.9953956,0.001847501,0.0005261367,0.0000950429,0.00001953006,0.00003427211,0.0004990599,0.000007708206,0.00157509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749914,"threshold_uncertainty_score":0.005854011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009911559995814261,"score_gpt":0.246553104038173,"score_spread":0.2366415440423587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}