{"id":"W2019253192","doi":"10.1042/bj20041625","title":"Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels","year":2005,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Heart and Stroke Foundation of Canada","keywords":"HEK 293 cells; Exocytosis; Syntaxin; Cell biology; Chemistry; Molecular biology; Biology; Biochemistry; Receptor; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002781133,0.0002225367,0.0003434147,0.00006883152,0.00006851754,0.00003632795,0.0005743158,0.0003018271,0.0001336049],"category_scores_gemma":[0.00003856722,0.0001946737,0.0002812068,0.0001308924,0.000136066,0.00001685544,0.0001882059,0.0002246607,0.000006178474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003427777,"about_ca_system_score_gemma":0.0001482184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002879065,"about_ca_topic_score_gemma":0.000006147239,"domain_scores_codex":[0.9984353,0.00002716968,0.0005929592,0.000307901,0.0003250364,0.0003116004],"domain_scores_gemma":[0.9988806,0.000007636108,0.0003208073,0.0003196274,0.0002543418,0.0002169653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006972119,0.0002142407,0.001012817,0.00004200307,0.0001189859,0.000007106519,0.0002136408,0.000006845116,0.9947221,0.00001547951,0.001609915,0.001339656],"study_design_scores_gemma":[0.0009270101,0.0005111907,0.0004300802,0.000130085,0.00006528912,0.0001557819,0.0001400166,0.00006260899,0.9830235,0.00008404378,0.01423839,0.0002319615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956035,0.001641633,0.001291149,0.0007231187,0.0002218128,0.0002099671,0.00004182943,0.000005150609,0.0002618174],"genre_scores_gemma":[0.9965222,0.0005556337,0.001229995,0.0002145581,0.0007885544,0.00000421715,0.0003504026,0.00002892103,0.0003055095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01262848,"threshold_uncertainty_score":0.7938564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134562088219793,"score_gpt":0.2560837572716065,"score_spread":0.2426275484496272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}