{"id":"W2019285763","doi":"10.1097/mnh.0000000000000084","title":"Sodium–glucose cotransporter-2 inhibition and the potential for renal protection in diabetic nephropathy","year":2014,"lang":"en","type":"review","venue":"Current Opinion in Nephrology & Hypertension","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Tubuloglomerular feedback; Glomerular hyperfiltration; Macula densa; Medicine; Renal glucose reabsorption; Diabetic nephropathy; Internal medicine; Endocrinology; Renal function; Albuminuria; Renal sodium reabsorption; Diabetes mellitus; Dapagliflozin; Nephropathy; Type 2 diabetes; Kidney; Renin–angiotensin system; Blood pressure; Reabsorption","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000796875,0.0005155873,0.001986062,0.0006110086,0.0001086438,0.00002827533,0.00009378426,0.0004304252,0.00001067049],"category_scores_gemma":[0.0000603048,0.0003344631,0.0004111918,0.0003048465,0.0002969363,0.00008575878,0.00008337064,0.0006088183,0.00001700554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001337155,"about_ca_system_score_gemma":0.00008979254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001796349,"about_ca_topic_score_gemma":0.00001080138,"domain_scores_codex":[0.9972019,0.0003994498,0.000956714,0.0007409469,0.0002194003,0.0004815765],"domain_scores_gemma":[0.9989193,0.0001637519,0.0003589903,0.0003914184,0.00007726518,0.0000892841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007299687,0.0004916782,0.00002744394,0.01526941,0.0001227688,0.00001352804,0.00004996145,0.000003413606,0.00003307093,0.0003342891,0.001176714,0.9817477],"study_design_scores_gemma":[0.01289372,0.0007125964,0.0005412435,0.01632354,0.001572094,0.0001068559,0.00001069042,0.001592302,0.000003720806,0.0005016659,0.9654018,0.0003397877],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004393094,0.9836401,0.0006099778,0.0009377559,0.002532439,0.007802975,0.00001631031,0.00005544676,0.00001190676],"genre_scores_gemma":[0.003163108,0.9921127,0.00007296279,0.0002537167,0.0007093172,0.002477188,0.00113376,0.00005855188,0.00001868014],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9814079,"threshold_uncertainty_score":0.9999107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0483187438579669,"score_gpt":0.3076721633883372,"score_spread":0.2593534195303703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}