{"id":"W2019406798","doi":"10.1074/jbc.m309398200","title":"Multiple and Distinct Effects of Mutations of Tyr122, Glu123, Arg324, and Arg334 Involved in Interactions between the Top Part of Second and Fourth Transmembrane Helices in Sarcoplasmic Reticulum Ca2+-ATPase","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Endoplasmic reticulum; Transmembrane protein; Transmembrane domain; ATPase; Chemistry; Biophysics; Membrane; Cell biology; Biology; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072348,0.0008680381,0.000324658,0.0001592292,0.0001483952,0.0002218191,0.0003874593,0.0004799021,0.001027323],"category_scores_gemma":[0.0003885331,0.0001736395,0.0004446533,0.0001423119,0.0004425291,0.0002209961,0.0002786992,0.0006857364,0.0002347344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894064,"about_ca_system_score_gemma":0.0001660301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004247827,"about_ca_topic_score_gemma":0.0004872249,"domain_scores_codex":[0.9997749,0.00005928849,0.00003494693,0.00004669059,0.00004850759,0.00003577169],"domain_scores_gemma":[0.9997422,0.000081531,0.00008628397,0.00002565093,0.00001543191,0.00004892897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003872289,0.00009533233,0.0004893102,0.00004560945,0.00002848687,0.0004407572,0.00002213065,0.000327964,0.9965024,0.0001063078,0.00001708502,0.001537367],"study_design_scores_gemma":[0.00008696171,0.001349565,0.006965708,0.00001438411,0.0001593274,0.001996365,0.00006538342,0.003264316,0.9851509,0.000141105,0.0007799027,0.0000261464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987785,0.000171957,0.0007167925,0.00001697228,0.0000096569,0.00001738454,0.00006259201,0.00001537683,0.0002107243],"genre_scores_gemma":[0.9985211,0.0001586059,0.0008815628,0.0000241634,0.000005574898,0.0000160342,0.0001078461,0.00001510249,0.0002700196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027323,"threshold_uncertainty_score":0.003436685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677089694286923,"score_gpt":0.2767064857375824,"score_spread":0.2599355887947132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}