{"id":"W2019417284","doi":"10.2165/00129785-200303030-00003","title":"Mutations in Cardiac Sodium Channels","year":2003,"lang":"en","type":"review","venue":"American Journal of PharmacoGenomics","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Sodium channel; Flecainide; Mexiletine; Lidocaine; Allosteric regulation; Cardiac action potential; Long QT syndrome; Ion channel; Pharmacology; Medicine; Sodium channel blocker; Channelopathy; Biophysics; Chemistry; Electrophysiology; Repolarization; Biology; Internal medicine; Anesthesia; Receptor; Sodium; QT interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004344712,0.001175818,0.001506781,0.002643654,0.0001966248,0.0006651242,0.0008335214,0.001000481,0.002320072],"category_scores_gemma":[0.0009427102,0.0002022468,0.0005744786,0.001911885,0.0003623102,0.0008188179,0.0005015523,0.0008930341,0.001465494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003597339,"about_ca_system_score_gemma":0.0005839332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005942783,"about_ca_topic_score_gemma":0.001044256,"domain_scores_codex":[0.9997329,0.00003549707,0.00005447881,0.00006520142,0.00008998474,0.00002191226],"domain_scores_gemma":[0.9995099,0.0002495158,0.000110915,0.00001838042,0.00007490838,0.00003635373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009420374,0.00007989884,0.0007312109,0.004133882,0.0001242923,0.00259481,0.00003497105,0.0003851085,0.004070658,0.001158878,0.02319927,0.9633929],"study_design_scores_gemma":[0.00009382502,0.0002149994,0.004269965,0.003646032,0.0007146136,0.02738706,0.00006231388,0.0003468384,0.003552709,0.001998809,0.9576749,0.0000378427],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00121275,0.9929382,0.001150969,0.0007093251,0.0006156244,0.00001418025,0.00006031146,0.00004770525,0.003250874],"genre_scores_gemma":[0.004429125,0.9905102,0.001161396,0.0008692925,0.0008528464,0.00001540679,0.0001254197,0.000007410844,0.002028931],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002643654,"threshold_uncertainty_score":0.007761419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02680555089991319,"score_gpt":0.3516598507195596,"score_spread":0.3248542998196464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}