{"id":"W2019435498","doi":"10.1089/oli.2008.0157","title":"siRNA-Mediated Integrin-Linked Kinase Suppression: Nonspecific Effects of siRNA/Cationic Liposome Complexes Trigger Changes in the Expression of Phosphorylated-AKT and mTOR Independently of ILK Silencing","year":2009,"lang":"en","type":"article","venue":"Oligonucleotides","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Integrin-linked kinase; Protein kinase B; Small interfering RNA; Gene silencing; Cationic liposome; PTEN; Cancer research; Nucleofection; Biology; Cell biology; Small hairpin RNA; Phosphorylation; Signal transduction; Transfection; Gene knockdown; Cell culture; Apoptosis; Biochemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214401,0.000185523,0.0003242174,0.0001262111,0.00004369743,0.00001413351,0.0003196087,0.0001641259,0.00002017769],"category_scores_gemma":[0.0001637012,0.0001340567,0.00008028978,0.000165426,0.0001451293,0.00001412171,0.00008455371,0.0001400759,0.000001646173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009606255,"about_ca_system_score_gemma":0.00004001344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007359813,"about_ca_topic_score_gemma":0.00005535103,"domain_scores_codex":[0.998794,0.0001305772,0.0004003733,0.000279677,0.0002000171,0.0001953273],"domain_scores_gemma":[0.9990261,0.0001322822,0.0002880837,0.000367175,0.0001393926,0.00004693649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002276442,0.0002163669,0.001803207,0.0001176455,0.00002095454,0.000005469467,0.0007884028,0.00002306397,0.9944928,0.00002869266,0.0003067548,0.001968952],"study_design_scores_gemma":[0.000730294,0.000897712,0.03519688,0.0004633297,0.00002343609,0.000005632643,0.0004934485,0.00003623701,0.9618043,0.0000933472,0.0001236341,0.0001316984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962996,0.002989049,0.00001618562,0.0001136882,0.0001053607,0.0003002586,0.00002145159,0.000006746824,0.0001476499],"genre_scores_gemma":[0.9982181,0.001416104,0.0001018196,0.00008451574,0.00005843417,0.00001179543,0.00005015268,0.00001202838,0.00004709559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03339367,"threshold_uncertainty_score":0.5466672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008955531124150479,"score_gpt":0.2346242456216639,"score_spread":0.2256687144975134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}