{"id":"W2019435498","doi":"10.1089/oli.2008.0157","title":"siRNA-Mediated Integrin-Linked Kinase Suppression: Nonspecific Effects of siRNA/Cationic Liposome Complexes Trigger Changes in the Expression of Phosphorylated-AKT and mTOR Independently of ILK Silencing","year":2009,"lang":"en","type":"article","venue":"Oligonucleotides","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Integrin-linked kinase; Protein kinase B; Small interfering RNA; Gene silencing; Cationic liposome; PTEN; Cancer research; Nucleofection; Biology; Cell biology; Small hairpin RNA; Phosphorylation; Signal transduction; Transfection; Gene knockdown; Cell culture; Apoptosis; Biochemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003270691,0.0005840053,0.0004496025,0.0002343846,0.0001653348,0.0003951628,0.0002748221,0.0004587218,0.001151044],"category_scores_gemma":[0.0001698821,0.0001777322,0.0004055755,0.0002510336,0.0004074811,0.0003477298,0.0002318389,0.0006344476,0.0003843327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754476,"about_ca_system_score_gemma":0.0003030061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000776485,"about_ca_topic_score_gemma":0.001212156,"domain_scores_codex":[0.9996185,0.00006000808,0.00004970339,0.0001072933,0.00007677778,0.00008776263],"domain_scores_gemma":[0.9998612,0.00003997562,0.00003625749,0.00001475031,0.00002070712,0.00002706098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008510388,0.00002068143,0.00002243396,0.00003059406,0.000003776899,0.00001774984,0.00001195986,0.00003042557,0.999252,0.00005110244,0.00002328879,0.0004509375],"study_design_scores_gemma":[0.00001034921,0.0001207672,0.0003387142,0.000001604564,0.000006720127,0.00003350378,0.000005208664,0.0003595549,0.9986475,0.000007588397,0.0004667018,0.0000018855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989345,0.001242369,0.006166236,0.0001039089,0.00005794544,0.000133254,0.0003941423,0.0001890352,0.002368111],"genre_scores_gemma":[0.991288,0.000673105,0.00468366,0.00007352357,0.00001119714,0.0001548099,0.0005192905,0.00005121111,0.002545167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151044,"threshold_uncertainty_score":0.003850639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008955531124150479,"score_gpt":0.2346242456216639,"score_spread":0.2256687144975134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}