{"id":"W2019449222","doi":"10.1016/j.jalz.2014.07.140","title":"P4‐371: PRECLINICAL DEVELOPMENT OF AN AMYLOID‐B OLIGMER (ABO) SPECIFIC MONOCLONAL ANTIBODY (5E3) FOR POTENTIAL PASSIVE IMMUNOTHERAPY OF ALZHEIMER'S DISEASE","year":2014,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Emergent BioSolutions (Canada)","funders":"","keywords":"Epitope; Monoclonal antibody; Antibody; In vivo; In vitro; Chemistry; Conformational epitope; Molecular biology; Genetically modified mouse; Humanized antibody; Immunology; Cancer research; Transgene; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005726194,0.0009682503,0.0005299379,0.0005306974,0.0003107162,0.000523734,0.0007522563,0.0007249791,0.002675216],"category_scores_gemma":[0.000149522,0.0002893128,0.0004044136,0.0002229625,0.0002827009,0.000458736,0.0002084581,0.00156688,0.0009994755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006618308,"about_ca_system_score_gemma":0.0009124994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001632462,"about_ca_topic_score_gemma":0.002523153,"domain_scores_codex":[0.9998447,0.00002171062,0.000008680054,0.00002342555,0.00003556657,0.00006599486],"domain_scores_gemma":[0.9999199,0.00000739748,0.00001244777,0.000008033105,0.00001722277,0.00003509034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003044859,0.004039043,0.0003875052,0.0003180177,0.00007318893,0.0002142985,0.00009656914,0.001025692,0.971348,0.0005915989,0.001344027,0.01751711],"study_design_scores_gemma":[0.001442446,0.0439642,0.003893221,0.00007268102,0.0002582284,0.0006278568,0.00007501627,0.002270364,0.9252619,0.0003793594,0.02172814,0.00002670477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800205,0.004918098,0.006391121,0.0003479511,0.0001676551,0.001101117,0.001917886,0.0002538152,0.004881862],"genre_scores_gemma":[0.9747379,0.005450813,0.00482776,0.0002205903,0.00005496831,0.0009784837,0.003024359,0.00004320845,0.01066193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002675216,"threshold_uncertainty_score":0.008949459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04676801350391865,"score_gpt":0.3567529555438578,"score_spread":0.3099849420399391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}