{"id":"W2019454741","doi":"10.1016/j.vetpar.2015.04.002","title":"Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance","year":2015,"lang":"en","type":"article","venue":"Veterinary Parasitology","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph; Jewish General Hospital; McGill University and Génome Québec Innovation Centre; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Health Canada; U.S. Department of Agriculture","keywords":"Dirofilaria immitis; Biology; Ivermectin; Moxidectin; SNP; Drug resistance; Single-nucleotide polymorphism; Genetics; Veterinary medicine; Gene; Genotype; Immunology; Helminths; Zoology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005457285,0.0002686132,0.0002979559,0.0004978304,0.0001727436,0.0003569429,0.0002340677,0.0003729201,0.0007159553],"category_scores_gemma":[0.001320222,0.0001108957,0.0001739656,0.0003050018,0.0003741231,0.0002972653,0.0001161476,0.0002628817,0.0001490291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196275,"about_ca_system_score_gemma":0.0001775778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001990056,"about_ca_topic_score_gemma":0.001334425,"domain_scores_codex":[0.9997165,0.0000964439,0.00002807283,0.00005222016,0.00005351289,0.00005321081],"domain_scores_gemma":[0.9993064,0.0002612607,0.0001348837,0.00006746572,0.0001280145,0.000101923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005846096,0.0008335613,0.6702082,0.0001601832,0.00008974013,0.003100524,0.0006156277,0.0003736956,0.233022,0.0004645943,0.0004551049,0.08483072],"study_design_scores_gemma":[0.00007738709,0.003996222,0.9395829,0.00002839298,0.0001964939,0.006092332,0.0004017718,0.001524817,0.04613599,0.0002642005,0.001679227,0.00002032083],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983619,0.0005000342,0.0002673018,0.00007369374,0.000005594032,0.000006624187,0.00006597667,0.00001133019,0.0007075098],"genre_scores_gemma":[0.9995196,0.0001391695,0.0001101052,0.00001793434,0.000005981825,0.000002307057,0.00003855836,0.000002302733,0.0001640249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990056,"threshold_uncertainty_score":0.003956974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03947159443011373,"score_gpt":0.3586884174117714,"score_spread":0.3192168229816577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}