{"id":"W2019454741","doi":"10.1016/j.vetpar.2015.04.002","title":"Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance","year":2015,"lang":"en","type":"article","venue":"Veterinary Parasitology","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph; Jewish General Hospital; McGill University and Génome Québec Innovation Centre; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Health Canada; U.S. Department of Agriculture","keywords":"Dirofilaria immitis; Biology; Ivermectin; Moxidectin; SNP; Drug resistance; Single-nucleotide polymorphism; Genetics; Veterinary medicine; Gene; Genotype; Immunology; Helminths; Zoology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478022,0.0001191674,0.0003871596,0.0001368594,0.00001930104,0.000003563409,0.00005818187,0.00007811648,0.000007919761],"category_scores_gemma":[0.0001472377,0.000113695,0.00005224649,0.0001457648,0.0003087318,0.00005885473,0.00002947621,0.00006246368,0.000001487798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000524376,"about_ca_system_score_gemma":0.0001425478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005036488,"about_ca_topic_score_gemma":0.0002678728,"domain_scores_codex":[0.9988809,0.000153371,0.0003256534,0.0002498379,0.0001491152,0.0002411032],"domain_scores_gemma":[0.999231,0.0001678013,0.0001165013,0.000212532,0.00008494017,0.0001872467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01155974,0.000284264,0.9526845,0.001110187,0.0001672399,0.0003938893,0.0004411063,0.000002364047,0.0314669,0.0005355329,0.0009558186,0.0003984427],"study_design_scores_gemma":[0.003428063,0.001617909,0.9897888,0.000302904,0.00006525793,0.00006961507,0.0001273588,0.00002395814,0.002046454,0.001794465,0.000649562,0.00008567041],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939833,0.004190755,0.0001115968,0.0004532795,0.00003714564,0.0006686278,0.00006601487,0.000009158418,0.0004801232],"genre_scores_gemma":[0.9866585,0.0001136118,0.01260426,0.00002047207,0.0000165948,0.0001314025,0.00004151317,0.00001180352,0.0004018332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03710427,"threshold_uncertainty_score":0.4636347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03947159443011373,"score_gpt":0.3586884174117714,"score_spread":0.3192168229816577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}