{"id":"W2019464259","doi":"10.1002/1521-4141(2000)30:8<2404::aid-immu2404>3.0.co;2-9","title":"Specific antibody production by VH-gene replacement","year":2000,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Medical Research Council Canada; University of Toronto; Cancer Research Society","keywords":"Biology; Gene; Immunoglobulin heavy chain; Antigen; Antibody; Molecular biology; Monoclonal antibody; Genetics; Gene rearrangement; Immunoglobulin light chain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002817014,0.0003530702,0.000308974,0.0002510963,0.0001036282,0.0002637936,0.0003918845,0.0003349507,0.0009287117],"category_scores_gemma":[0.0002014353,0.000209223,0.0002705331,0.00015262,0.0002141914,0.0001512371,0.0003429387,0.0005165093,0.00041543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258806,"about_ca_system_score_gemma":0.0001095472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002499626,"about_ca_topic_score_gemma":0.0003039119,"domain_scores_codex":[0.9997118,0.00005081776,0.00002451525,0.00006358579,0.00006807721,0.00008116033],"domain_scores_gemma":[0.9998389,0.00003532906,0.00004346874,0.00003977251,0.00001789008,0.00002452744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001436751,0.000009326969,0.00007709536,0.00001231963,0.000002006923,0.00001978134,0.000005499071,0.00003794501,0.9990584,0.0001048069,0.00001718997,0.0006411565],"study_design_scores_gemma":[0.00001523032,0.0001864056,0.0007309876,0.000002690006,0.000009970935,0.0001787506,0.000005694531,0.0005133489,0.9964564,0.0000477021,0.001850319,0.000002427128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766173,0.0006612286,0.01933231,0.00008660752,0.00004611725,0.00009653662,0.0002270324,0.0002104552,0.00272249],"genre_scores_gemma":[0.9891521,0.0003863372,0.00741866,0.000052359,0.00001225932,0.00003074131,0.0003621473,0.00003850056,0.002546869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009287117,"threshold_uncertainty_score":0.003106833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899201639579834,"score_gpt":0.2870819748802056,"score_spread":0.2680899584844073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}