{"id":"W2019465092","doi":"10.1158/1538-7445.am10-3890","title":"Abstract 3890: Induction of cell cycle arrest and apoptosis in mantle cell lymphoma by AZD5438, a novel cyclin-dependent kinase inhibitor","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Cyclin-dependent kinase; Cell cycle; Cyclin-dependent kinase 1; Mantle cell lymphoma; Cell cycle checkpoint; Cyclin B; Cyclin B1; Cyclin D1; Cancer research; Cyclin A; Cell growth; Cyclin D; Kinase; Biology; Chemistry; Molecular biology; Cell biology; Apoptosis; Biochemistry; Immunology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008536449,0.0002973225,0.0002712159,0.0002444031,0.00009989592,0.000136776,0.0002318519,0.0001766735,0.00173242],"category_scores_gemma":[0.0001021719,0.00009419079,0.0001491018,0.0001823345,0.0001163239,0.0001143254,0.0001211085,0.0003480169,0.0002949155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002794765,"about_ca_system_score_gemma":0.0001544458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009519142,"about_ca_topic_score_gemma":0.001011855,"domain_scores_codex":[0.9999136,0.00001607698,0.000008487574,0.00001513873,0.00002332022,0.00002335783],"domain_scores_gemma":[0.9999679,0.000007640686,0.000008100345,0.000004449982,0.000003994621,0.000007785598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003090585,0.00008742604,0.0002457643,0.00004426288,0.000007075141,0.00006205924,0.000007073387,0.0002048966,0.9955257,0.00006769485,0.0001245788,0.003314398],"study_design_scores_gemma":[0.0001548133,0.003039478,0.004845282,0.000006755065,0.00002020415,0.0003446924,0.000008370685,0.001282083,0.9877638,0.00003699609,0.002493361,0.000004064843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938743,0.002380756,0.0009330089,0.000108911,0.0000263517,0.00005270638,0.0005928496,0.0001242927,0.001906863],"genre_scores_gemma":[0.9958909,0.0009509387,0.001057744,0.00003594494,0.00001054505,0.00003794834,0.0008255109,0.0000107627,0.001179754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173242,"threshold_uncertainty_score":0.005795479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03226406844666833,"score_gpt":0.339952562499045,"score_spread":0.3076884940523766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}