{"id":"W2019472718","doi":"10.1021/ja031698u","title":"Glycodendriproteins:  A Synthetic Glycoprotein Mimic Enzyme with Branched Sugar-Display Potently Inhibits Bacterial Aggregation","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Bacterial adhesin; Chemistry; Bacteria; Virulence; Glycoprotein; Enzyme; Small molecule; Biochemistry; Virulence factor; Microbiology; Pathogenic bacteria; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065775,0.0003051505,0.0001640467,0.00009037979,0.00008987847,0.0002465368,0.0001721874,0.000267414,0.0003239843],"category_scores_gemma":[0.0001027311,0.0001058365,0.0001353209,0.00009851337,0.0001747575,0.0001421525,0.0001521975,0.0003054479,0.0001810093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280511,"about_ca_system_score_gemma":0.0001346734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003369867,"about_ca_topic_score_gemma":0.0005148197,"domain_scores_codex":[0.9999001,0.00001641987,0.00000680035,0.00001686964,0.00003855825,0.0000212996],"domain_scores_gemma":[0.9999503,0.000007022573,0.00001507295,0.000005898122,0.000004330032,0.00001751953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003550109,0.00002058063,0.00003692578,0.00001025427,0.000003033852,0.0000265704,0.000005006515,0.00009582577,0.9986987,0.0000732919,0.00003307377,0.0009613338],"study_design_scores_gemma":[0.000008879836,0.000178351,0.0003276659,8.557676e-7,0.000005387136,0.000111852,0.000002091112,0.0006212945,0.9977517,0.00001159481,0.000978393,0.000002012813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915581,0.001107598,0.005410878,0.00007698642,0.00002508744,0.00002854249,0.00009981461,0.00009974628,0.001593228],"genre_scores_gemma":[0.9921793,0.0006940826,0.004864756,0.00005529454,0.00001025689,0.0000162886,0.0002320159,0.00002822513,0.001919745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003369867,"threshold_uncertainty_score":0.001654625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004235390959104566,"score_gpt":0.2028026280659552,"score_spread":0.1985672371068506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}