{"id":"W2019507798","doi":"10.1074/jbc.m109.029538","title":"Bin1 Src Homology 3 Domain Acts as a Scaffold for Myofiber Sarcomere Assembly","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; Ottawa Hospital; Stem Cell Network","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Association; Heart and Stroke Foundation of Canada","keywords":"Sarcomere; Myocyte; Scaffold; Proto-oncogene tyrosine-protein kinase Src; Cell biology; Chemistry; Scaffold protein; Homology (biology); Biophysics; Biology; Biochemistry; Phosphorylation; Amino acid; Signal transduction; Medicine; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003081845,0.0002194041,0.0003643312,0.00002599859,0.00008600191,0.00001456378,0.000376522,0.0005706231,0.00009717171],"category_scores_gemma":[0.0003435289,0.0001607963,0.0003579691,0.00007272959,0.0001111369,0.0000060515,0.00005862463,0.0002114084,0.000006653805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002722762,"about_ca_system_score_gemma":0.000109817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.092246e-7,"about_ca_topic_score_gemma":5.125631e-7,"domain_scores_codex":[0.9987528,0.00006145657,0.0004186184,0.0002983024,0.00009961534,0.0003691967],"domain_scores_gemma":[0.9990399,0.00006178653,0.0003249468,0.00023005,0.0001631859,0.0001801143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001113904,0.0002328418,0.0003527294,0.00001628828,0.0000741084,0.00001562171,0.000009477372,0.0000126678,0.9920812,0.00008483916,0.004379171,0.001627135],"study_design_scores_gemma":[0.002117445,0.003114323,0.003691518,0.00002504344,0.00003348898,0.0004445441,0.0001131843,0.000003680631,0.9239887,0.01203685,0.05407594,0.0003553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930718,0.001254833,0.0005072623,0.001620896,0.0001061223,0.0001063222,0.00001256165,0.000009178501,0.00331104],"genre_scores_gemma":[0.9958238,0.0002404486,0.001294404,0.00158644,0.0005964319,0.00000627709,0.00006120963,0.0000099822,0.000381008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06809254,"threshold_uncertainty_score":0.6557082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475598554988377,"score_gpt":0.2755100619848843,"score_spread":0.2607540764350005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}