{"id":"W2019530610","doi":"10.1016/j.devcel.2007.01.018","title":"DRE-1: An Evolutionarily Conserved F Box Protein that Regulates C. elegans Developmental Age","year":2007,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"National Institutes of Health; Max-Planck-Gesellschaft; Emerald Foundation","keywords":"Biology; Heterochrony; Caenorhabditis elegans; Skp1; Cullin; Ubiquitin ligase; Genetics; F-box protein; Phenotype; RNA interference; Ubiquitin-Protein Ligases; Genetic screen; Model organism; Cell biology; Developmental biology; Drosophila melanogaster; Gene; Ubiquitin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143143,0.0006051706,0.0002963606,0.0004857878,0.0004226587,0.0003073862,0.0004882586,0.0005381905,0.00213362],"category_scores_gemma":[0.0002030876,0.0001788961,0.0002263795,0.0001616275,0.0003398181,0.0003855762,0.0003577684,0.0006821001,0.0008633483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004541691,"about_ca_system_score_gemma":0.0002842742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008277549,"about_ca_topic_score_gemma":0.001803753,"domain_scores_codex":[0.9998997,0.000004862952,0.000003603432,0.000045448,0.00002511891,0.00002115539],"domain_scores_gemma":[0.9999048,0.000008257335,0.00002993121,0.000007299746,0.00001309215,0.00003663194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000117605,0.00001715107,0.0004158019,0.0000623168,0.000005432028,0.0002264557,0.00001251114,0.0001018934,0.9910222,0.0004205478,0.0008334824,0.006764554],"study_design_scores_gemma":[0.00004730342,0.0001795001,0.02535666,0.00003697298,0.00003970001,0.002788614,0.00004599984,0.001730936,0.9421326,0.000577093,0.02701266,0.00005210164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9393585,0.01437204,0.02741824,0.0007691613,0.0004473351,0.00008210766,0.003898076,0.003004985,0.01064952],"genre_scores_gemma":[0.9602932,0.002971577,0.01361307,0.0003392216,0.00005429455,0.00005375343,0.002220714,0.0002038561,0.02025035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00213362,"threshold_uncertainty_score":0.007137656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01500990026484258,"score_gpt":0.2168407638250501,"score_spread":0.2018308635602075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}