{"id":"W2019535767","doi":"10.1172/jci63681","title":"IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Gemeinnützige Hertie-Stiftung; Deutsche Forschungsgemeinschaft; Philipps-Universität Marburg","keywords":"Adoptive cell transfer; Experimental autoimmune encephalomyelitis; CD8; Immunology; Interleukin 17; Cytotoxic T cell; Autoimmunity; Interleukin 21; Biology; Interleukin 3; T cell; Multiple sclerosis; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002853934,0.0002460209,0.0007449339,0.00014802,0.0001582465,0.00002348415,0.0003187456,0.0008383654,0.001378703],"category_scores_gemma":[0.001090539,0.0002009996,0.0003442304,0.0002047947,0.0007683946,0.0006045027,0.00007188044,0.001235744,0.0009442125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005194389,"about_ca_system_score_gemma":0.0002341628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004834023,"about_ca_topic_score_gemma":0.000002348431,"domain_scores_codex":[0.9957843,0.001056319,0.002263633,0.0002255249,0.0001308255,0.0005393274],"domain_scores_gemma":[0.9964206,0.001007027,0.001817366,0.0002767041,0.0003109131,0.0001674429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001366984,0.0002967505,0.01435998,0.000012629,0.0001902052,0.000007274605,0.000327549,0.000002629241,0.9394343,0.0001608347,0.04089974,0.004171445],"study_design_scores_gemma":[0.004372468,0.001445155,0.07260004,0.0001534208,0.0002981657,0.0004505663,0.0003498086,0.00002407721,0.4757759,0.001507102,0.4425254,0.0004978639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858141,0.004364721,0.0002763433,0.001458809,0.00735225,0.000163319,0.00003786029,0.00005019714,0.0004824005],"genre_scores_gemma":[0.9946025,0.001050569,0.0003598981,0.0008831156,0.0005087559,0.000004537564,0.0003116448,0.00002427368,0.002254702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4636583,"threshold_uncertainty_score":0.9998336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150100175211817,"score_gpt":0.2967154192785993,"score_spread":0.2652144175264812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}