{"id":"W2019541045","doi":"10.1007/s00221-011-2994-3","title":"Modulation of voltage-gated sodium channels hyperpolarizes the voltage threshold for activation in spinal motoneurones","year":2012,"lang":"en","type":"article","venue":"Experimental Brain Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Purdue Pharma (Canada); Ontario Tech University","funders":"Canadian Institutes of Health Research; Health Sciences Centre Foundation","keywords":"Hyperpolarization (physics); Veratridine; Depolarization; Sodium channel; Chemistry; Tetrodotoxin; Membrane potential; Electrophysiology; Neuroscience; Biophysics; Reversal potential; Spinal cord; Patch clamp; Sodium; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009333121,0.0001014721,0.00009355539,0.0001285089,0.0001550598,0.00002294574,0.0001309533,0.0001191124,0.00002830951],"category_scores_gemma":[0.0001803892,0.0000826277,0.00005909147,0.0001995869,0.0001249947,0.00002559284,0.00009041364,0.0001159375,0.000004435601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004492316,"about_ca_system_score_gemma":0.00002992803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005011367,"about_ca_topic_score_gemma":0.000002350688,"domain_scores_codex":[0.9988843,0.0001007355,0.0001965289,0.0002088668,0.0002896633,0.000319971],"domain_scores_gemma":[0.9995141,0.00005411192,0.00005524113,0.0002030485,0.0001211422,0.00005235901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005764393,0.0001797587,0.001077241,0.00001399921,0.00001019913,6.850403e-8,0.0003504803,0.0001511117,0.9947559,0.0009038564,0.00131361,0.0006673815],"study_design_scores_gemma":[0.0006983989,0.0004406686,0.008742701,0.00001287779,0.000001002976,0.000001445152,0.001003463,0.006498212,0.9773902,0.00009944027,0.005021465,0.00009012856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931288,0.0002946888,0.004735522,0.0004977049,0.0003402222,0.0007516948,0.000005503272,0.00000785888,0.0002379804],"genre_scores_gemma":[0.9980996,0.000005832134,0.00006566932,0.0001037555,0.0005869603,0.0001354714,0.0001448668,0.00001996978,0.0008378322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01736566,"threshold_uncertainty_score":0.336946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07607040387811176,"score_gpt":0.3750335528624147,"score_spread":0.2989631489843029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}