{"id":"W2019559983","doi":"10.1006/dbio.2002.0680","title":"Inhibition of MEK or cdc2 Kinase Parthenogenetically Activates Mouse Eggs and Yields the Same Phenotypes as Mos−/− Parthenogenotes","year":2002,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; MAPK/ERK pathway; Parthenogenesis; Cyclin-dependent kinase 1; Human fertilization; Maturation promoting factor; Phenotype; Kinase; Protein kinase A; Metaphase; Cell biology; MEK inhibitor; Molecular biology; Embryo; Genetics; Cell cycle; Apoptosis; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002437255,0.001104828,0.0005285431,0.001057452,0.0003449795,0.0007505431,0.0006938613,0.0007894807,0.006253663],"category_scores_gemma":[0.0002455008,0.0006047825,0.0005671132,0.0003579581,0.0007740821,0.0004076926,0.0005393262,0.001853104,0.002204896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004963273,"about_ca_system_score_gemma":0.0003357588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001602773,"about_ca_topic_score_gemma":0.002959179,"domain_scores_codex":[0.9994904,0.00004790679,0.00007156678,0.0001021695,0.0001808195,0.0001070151],"domain_scores_gemma":[0.9993376,0.0001448227,0.0001683492,0.0001088352,0.00002849557,0.0002118713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009532979,0.00001833879,0.0001014211,0.00002129551,0.000006687983,0.0001040223,0.00001495624,0.00005522704,0.9985622,0.0003311815,0.00005673195,0.0006327417],"study_design_scores_gemma":[0.00001629821,0.00004116531,0.001527042,0.000004104894,0.000009683633,0.0002118,0.00002571992,0.0003094806,0.9960968,0.00005960144,0.001694055,0.000004289864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736636,0.001926522,0.009019637,0.0004382722,0.0003232796,0.0001352752,0.002807209,0.0006692596,0.01101708],"genre_scores_gemma":[0.9503083,0.001432293,0.005674798,0.0002151702,0.00004866023,0.0001508182,0.002128785,0.0005670721,0.039474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006253663,"threshold_uncertainty_score":0.02092057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0367864931952753,"score_gpt":0.2777065943998845,"score_spread":0.2409201012046092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}