{"id":"W2019560480","doi":"10.1021/jm100803c","title":"Antiviral Activity of Various 1-(2′-Deoxy-β-d-lyxofuranosyl), 1-(2′-Fluoro-β-d-xylofuranosyl), 1-(3′-Fluoro-β-d-arabinofuranosyl), and 2′-Fluoro-2′,3′-didehydro-2′,3′-dideoxyribose Pyrimidine Nucleoside Analogues against Duck Hepatitis B Virus (DHBV) and Human Hepatitis B Virus (HBV) Replication","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Lamivudine; Chemistry; Hepatitis B virus; Virology; Uracil; Nucleoside; Thymine; Virus; Stereochemistry; Cytotoxicity; Molecular biology; In vitro; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.003570414,0.002384493,0.004928859,0.001100562,0.001221725,0.000338242,0.001454615,0.001871271,0.00009171767],"category_scores_gemma":[0.01746389,0.002268058,0.001161578,0.001496529,0.0031873,0.001693084,0.0008665719,0.005132896,0.00004661889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006895548,"about_ca_system_score_gemma":0.001102622,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009671188,"about_ca_topic_score_gemma":0.005754807,"domain_scores_codex":[0.9861183,0.0005890983,0.004658681,0.002550773,0.003611563,0.002471615],"domain_scores_gemma":[0.9830682,0.004504531,0.00499058,0.002693823,0.00246349,0.002279412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001601189,0.001231679,0.2333255,0.001571552,0.001201651,0.001445588,0.002916858,0.000007938444,0.7362046,0.00005950391,0.01500696,0.006868117],"study_design_scores_gemma":[0.006742711,0.002142151,0.3226791,0.001814959,0.002043121,0.003280678,0.0007474159,0.0004578154,0.642216,0.0006636625,0.01669565,0.000516713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983478,0.006399883,0.0002357704,0.0007727009,0.00125637,0.001561947,0.0007799768,0.0003675992,0.00514778],"genre_scores_gemma":[0.9700038,0.02181857,0.002106864,0.0008680982,0.002812198,0.0001086605,0.0003150082,0.0004385991,0.001528235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09398857,"threshold_uncertainty_score":0.9995254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288353217369414,"score_gpt":0.2656923849963177,"score_spread":0.2528088528226236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}