{"id":"W2019560480","doi":"10.1021/jm100803c","title":"Antiviral Activity of Various 1-(2′-Deoxy-β-d-lyxofuranosyl), 1-(2′-Fluoro-β-d-xylofuranosyl), 1-(3′-Fluoro-β-d-arabinofuranosyl), and 2′-Fluoro-2′,3′-didehydro-2′,3′-dideoxyribose Pyrimidine Nucleoside Analogues against Duck Hepatitis B Virus (DHBV) and Human Hepatitis B Virus (HBV) Replication","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Lamivudine; Chemistry; Hepatitis B virus; Virology; Uracil; Nucleoside; Thymine; Virus; Stereochemistry; Cytotoxicity; Molecular biology; In vitro; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155481,0.0002619767,0.0001783398,0.0001477595,0.0001428429,0.0001362634,0.000159017,0.0002066178,0.0008822192],"category_scores_gemma":[0.0001311822,0.00008515181,0.0001607943,0.0001012089,0.0001464651,0.0001534971,0.00007635843,0.0002565342,0.0001517179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002001104,"about_ca_system_score_gemma":0.0001991146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005633566,"about_ca_topic_score_gemma":0.00110967,"domain_scores_codex":[0.9999346,0.00001914862,0.000006323475,0.00001401729,0.00001154575,0.00001433596],"domain_scores_gemma":[0.9999465,0.00001127742,0.00001397909,0.000004855125,0.000009023407,0.0000143959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002467052,0.00007792727,0.0002195971,0.000217458,0.000009972513,0.00009244592,0.00004541463,0.0006818714,0.9900604,0.0001981982,0.00005370814,0.008096408],"study_design_scores_gemma":[0.0000494014,0.002790691,0.001339558,0.00002283623,0.00003106115,0.0002155854,0.00002424771,0.0006133071,0.9907508,0.00002217729,0.004129193,0.00001116172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832161,0.01144358,0.00145956,0.00004843545,0.0000294992,0.00006605168,0.0002723241,0.00002741101,0.003437042],"genre_scores_gemma":[0.9921069,0.003822781,0.002491194,0.00004337344,0.00001001998,0.00003357936,0.0002613694,0.000004770202,0.001225989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008822192,"threshold_uncertainty_score":0.002951264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288353217369414,"score_gpt":0.2656923849963177,"score_spread":0.2528088528226236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}