{"id":"W2019577645","doi":"10.1074/jbc.m604252200","title":"Fer and Fps/Fes Participate in a Lyn-dependent Pathway from FcϵRI to Platelet-Endothelial Cell Adhesion Molecule 1 to Limit Mast Cell Activation","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"LYN; FYN; Degranulation; Syk; Mast cell; Cell biology; Phosphorylation; Kinase; Chemistry; Proto-oncogene tyrosine-protein kinase Src; Tyrosine phosphorylation; Tyrosine kinase; Protein tyrosine phosphatase; Receptor; Molecular biology; Signal transduction; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001734777,0.0001795988,0.0003395671,0.00004943998,0.00004982762,0.00002113304,0.000160932,0.0003095053,0.0006796396],"category_scores_gemma":[0.00005156773,0.000129881,0.00007428625,0.00007645122,0.00004824134,0.00003773615,0.00009721341,0.0003490447,0.00005847348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005761534,"about_ca_system_score_gemma":0.00002509011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001000749,"about_ca_topic_score_gemma":0.00001255089,"domain_scores_codex":[0.9988382,0.0000678791,0.0004883567,0.0002546019,0.00005715755,0.0002938047],"domain_scores_gemma":[0.9994305,0.000110792,0.0002110693,0.0001140058,0.00005790139,0.00007569342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000719989,0.0003188517,0.001708641,0.00001622364,0.00001001426,0.0000535031,0.0001083311,0.00003784932,0.9957051,0.00000264538,0.0004670632,0.0008517797],"study_design_scores_gemma":[0.0013165,0.0003359136,0.006580635,0.00004315591,0.000008931236,0.00002066383,0.0001275799,0.000001912795,0.97746,0.00007545008,0.01386731,0.0001619513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975041,0.00051852,0.00009470476,0.0002856821,0.00009911007,0.0001013692,0.00005732973,0.00001028025,0.001328974],"genre_scores_gemma":[0.9979998,0.00005179972,0.0002156989,0.0001834521,0.0001329057,0.000006565381,0.00003719784,0.000009254661,0.001363294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01824512,"threshold_uncertainty_score":0.7441577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511313255552335,"score_gpt":0.2106866248549966,"score_spread":0.1955734922994733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}