{"id":"W2019582440","doi":"10.1074/jbc.m307289200","title":"Transcriptional Activators Control Splicing and 3′-End Cleavage Levels","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"RNA splicing; Precursor mRNA; RNA polymerase II; Transcription (linguistics); Intron; Alternative splicing; Biology; Cell biology; Messenger RNA; Promoter; Post-transcriptional modification; Primary transcript; Cleavage (geology); RNA; Molecular biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004358081,0.000120424,0.000194365,0.000016196,0.00006705073,0.00002317381,0.0001231039,0.0001875357,0.0001053438],"category_scores_gemma":[0.00037418,0.00008511364,0.0001181894,0.00004338157,0.000125801,0.000005868684,0.00001709776,0.0002432986,9.007746e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001570625,"about_ca_system_score_gemma":0.00006894283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001203505,"about_ca_topic_score_gemma":2.565528e-7,"domain_scores_codex":[0.9991306,0.00006503802,0.0002657014,0.0001656263,0.000147391,0.0002256528],"domain_scores_gemma":[0.9994695,0.00003976602,0.0001272258,0.00009425528,0.000078085,0.0001911389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001540799,0.00004029182,0.006238126,0.00001263365,0.00005539637,0.00001633774,0.00000469042,0.000005465833,0.992512,0.00005911992,0.0001474326,0.0007543591],"study_design_scores_gemma":[0.001159076,0.0002804745,0.01193132,0.00001762522,0.00001035225,0.0003903859,0.00008732013,0.000006612582,0.9788638,0.0001846817,0.006943543,0.0001247573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995961,0.0009659622,0.001751019,0.0001152401,0.00003636087,0.00004077733,0.00001126283,0.000002818245,0.001115529],"genre_scores_gemma":[0.9987723,0.000185841,0.0003862789,0.0001605904,0.0001978117,0.000001394844,0.000003588332,0.000007183803,0.0002850665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01364822,"threshold_uncertainty_score":0.3470834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540527016974631,"score_gpt":0.2706380585343909,"score_spread":0.2452327883646446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}