{"id":"W2019582440","doi":"10.1074/jbc.m307289200","title":"Transcriptional Activators Control Splicing and 3′-End Cleavage Levels","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"RNA splicing; Precursor mRNA; RNA polymerase II; Transcription (linguistics); Intron; Alternative splicing; Biology; Cell biology; Messenger RNA; Promoter; Post-transcriptional modification; Primary transcript; Cleavage (geology); RNA; Molecular biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007834657,0.0003506707,0.0002828678,0.0002563723,0.0001601842,0.0008806008,0.0002551446,0.0003001058,0.001758124],"category_scores_gemma":[0.0006581747,0.0002347658,0.0004315587,0.0002349592,0.0003205573,0.0004099139,0.0003157733,0.0008187504,0.001027172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000302289,"about_ca_system_score_gemma":0.0002755976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001717288,"about_ca_topic_score_gemma":0.0003365544,"domain_scores_codex":[0.9992481,0.0001712113,0.00008447307,0.0001489988,0.000228939,0.0001182928],"domain_scores_gemma":[0.9987506,0.0005708488,0.0002343294,0.000114856,0.0002161572,0.0001131327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001151351,0.00002241825,0.001561023,0.00004481122,0.00000596172,0.00004185945,0.00002755176,0.00007329031,0.9954613,0.000280371,0.00001866606,0.002347684],"study_design_scores_gemma":[0.00001195644,0.0001929551,0.007901006,0.00001738465,0.00002636482,0.0001701534,0.00004772104,0.0008573395,0.9877372,0.0002951556,0.002735188,0.000007555031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757385,0.005756406,0.01420331,0.0001607872,0.00005985869,0.00004519138,0.0003876456,0.0001141069,0.003534121],"genre_scores_gemma":[0.9872816,0.001834683,0.007666938,0.00007283854,0.00002179965,0.00003018128,0.0007238776,0.00006688924,0.002301262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001758124,"threshold_uncertainty_score":0.005881548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540527016974631,"score_gpt":0.2706380585343909,"score_spread":0.2452327883646446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}