{"id":"W2019607858","doi":"10.1534/g3.114.010629","title":"A Recent Global Selective Sweep on the<i>age-1</i>Phosphatidylinositol 3-OH Kinase Regulator of the Insulin-Like Signaling Pathway Within<i>Caenorhabditis remanei</i>","year":2014,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Ontario Ministry of Research and Innovation; National Institute on Aging; National Institutes of Health; National Science Foundation","keywords":"Biology; Balancing selection; Natural selection; Insulin receptor; Genetics; Caenorhabditis elegans; Population; Evolutionary biology; Genetic variation; Regulator; Gene; Insulin; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006148192,0.000567784,0.0004594552,0.00004530073,0.0004451614,0.0000842813,0.001145532,0.0003641275,0.00002345376],"category_scores_gemma":[0.00006725213,0.0004237175,0.0002965616,0.0004007768,0.0004204793,0.000004831722,0.0004766759,0.0002625507,0.00002031204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000915323,"about_ca_system_score_gemma":0.0002988611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004083851,"about_ca_topic_score_gemma":0.0002006259,"domain_scores_codex":[0.9966103,0.0004728744,0.0007489717,0.0008765067,0.0006310273,0.0006602916],"domain_scores_gemma":[0.9971743,0.00007185779,0.0005278076,0.001595639,0.0004503268,0.0001801286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002008765,0.000334508,0.005981789,0.0000898251,0.0003766881,0.00000828678,0.001537659,0.03167886,0.7253763,0.0008579441,0.002244559,0.2313127],"study_design_scores_gemma":[0.0006907871,0.0007290485,0.00308799,0.00003771479,0.0001214297,0.0000280328,0.0001483263,0.000447253,0.8300747,0.0009636144,0.1631192,0.0005519284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8910381,0.102482,0.002297751,0.0006520641,0.001537374,0.001032155,0.0001847591,0.00004241136,0.0007334735],"genre_scores_gemma":[0.9756328,0.01753737,0.002652601,0.002920968,0.000706949,0.0000450618,0.00008779081,0.00009140065,0.0003250489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2307608,"threshold_uncertainty_score":0.9998215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009239723528209736,"score_gpt":0.2076630958920252,"score_spread":0.1984233723638155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}