{"id":"W2019614055","doi":"10.1016/j.ejpb.2006.11.026","title":"A comparison of the effectiveness of cationic polymers poly-l-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC)","year":2006,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polyethylenimine; Gene delivery; Genetic enhancement; Stromal cell; Molecular biology; Plasmid; Transfection; Chemistry; Green fluorescent protein; Bone marrow; Gene expression; Polylysine; Cell biology; Biophysics; Biology; Gene; Biochemistry; Cancer research; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000470975,0.0003145699,0.0002184865,0.0003524915,0.0001491901,0.0003264374,0.0001982798,0.0003829558,0.0008892158],"category_scores_gemma":[0.0005513032,0.0001417635,0.0002471636,0.0002415131,0.0001859238,0.0003949689,0.0001424779,0.0002771428,0.0001780615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395895,"about_ca_system_score_gemma":0.0002860558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006987349,"about_ca_topic_score_gemma":0.0007171155,"domain_scores_codex":[0.9997321,0.00006698096,0.00003620098,0.00004478495,0.0000787193,0.00004115035],"domain_scores_gemma":[0.9992633,0.0004349404,0.0001015875,0.00003376184,0.00009006402,0.00007625737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004816467,0.00005229736,0.0001956745,0.0001077688,0.00001077448,0.00003308172,0.00003324273,0.0001807482,0.994904,0.00007540198,0.00002133673,0.003904007],"study_design_scores_gemma":[0.00001292617,0.0006510802,0.0009671543,0.000003488926,0.00002236552,0.00006120265,0.000009623988,0.0003845049,0.9973596,0.00001326541,0.0005106711,0.000004068176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925305,0.003561483,0.002324818,0.00003507827,0.00003894203,0.00002505659,0.0001169009,0.00003305465,0.001334107],"genre_scores_gemma":[0.9936372,0.001666912,0.00278181,0.00002193988,0.00001626814,0.00002464876,0.000213929,0.0000169242,0.001620368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008892158,"threshold_uncertainty_score":0.002974689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900918046311929,"score_gpt":0.3012249093839799,"score_spread":0.2822157289208606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}