{"id":"W2019614055","doi":"10.1016/j.ejpb.2006.11.026","title":"A comparison of the effectiveness of cationic polymers poly-l-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC)","year":2006,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Polyethylenimine; Gene delivery; Genetic enhancement; Stromal cell; Molecular biology; Plasmid; Transfection; Chemistry; Green fluorescent protein; Bone marrow; Gene expression; Polylysine; Cell biology; Biophysics; Biology; Gene; Biochemistry; Cancer research; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009044871,0.0002213594,0.000431847,0.0001338153,0.00006903425,0.00001683545,0.0002871852,0.00005899125,0.000005376321],"category_scores_gemma":[0.00002848867,0.0001764938,0.0001978788,0.0001427517,0.0002444003,0.00001324401,0.0001849963,0.000166709,3.634614e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001417036,"about_ca_system_score_gemma":0.00009302262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001297848,"about_ca_topic_score_gemma":0.000003488567,"domain_scores_codex":[0.998229,0.000303252,0.0008102902,0.0002032292,0.0002222212,0.0002319909],"domain_scores_gemma":[0.9985075,0.00008914682,0.0007174106,0.0001803003,0.0003773772,0.0001282794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002025072,0.0002319108,0.006503767,0.0002971744,0.0001881862,0.000004114696,0.00008822958,0.0002611244,0.9867329,0.00001363432,0.0001960832,0.003457774],"study_design_scores_gemma":[0.002516235,0.00129101,0.008491268,0.000145347,0.0003328489,0.00003546349,0.000115363,0.0007263203,0.9839258,0.000006692573,0.002243214,0.0001705022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934689,0.004940417,0.0005914113,0.0001085766,0.0003168294,0.000286784,0.0001723387,0.00000177117,0.0001129809],"genre_scores_gemma":[0.9982,0.0007635776,0.0006524911,0.00009988244,0.0001738937,0.00000140832,0.00001317539,0.00002928609,0.00006628251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004731112,"threshold_uncertainty_score":0.719721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900918046311929,"score_gpt":0.3012249093839799,"score_spread":0.2822157289208606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}