{"id":"W2019628879","doi":"10.1186/1471-2091-10-9","title":"alpha-Sarcin catalytic activity is not required for cytotoxicity","year":2009,"lang":"en","type":"article","venue":"BMC Biochemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC","keywords":"Ribosome; Ricin; Protein biosynthesis; Biology; Cytoplasm; Ribosomal RNA; Mutant; Ribosome-inactivating protein; Cytotoxicity; Biochemistry; Cell biology; Programmed cell death; Ribosomal protein; RNA; Toxin; In vitro; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002069529,0.000272181,0.0003267697,0.00003905797,0.0002316275,0.00002535035,0.0003564257,0.0005120886,0.0002725682],"category_scores_gemma":[0.0001502613,0.0002655608,0.0002325029,0.0001009112,0.0001139012,0.00008756112,0.00006195583,0.0002519156,0.0001974173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008519792,"about_ca_system_score_gemma":0.0001422028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002229276,"about_ca_topic_score_gemma":0.00000231887,"domain_scores_codex":[0.9986234,0.00003184854,0.0002553487,0.0005257322,0.0000462392,0.000517379],"domain_scores_gemma":[0.9990377,0.00008605215,0.0001432954,0.0006293157,0.00006142635,0.00004219557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000392232,0.0001992715,0.00005931037,0.00004757791,0.00004362056,0.000001076533,0.00005956462,2.520991e-7,0.9898904,0.0001138325,0.006013956,0.003178912],"study_design_scores_gemma":[0.001537153,0.0001975458,0.002012073,0.00002814195,0.00004076641,0.00003042987,0.00004544841,0.00001841587,0.9916577,0.0003000815,0.003811325,0.0003209464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930798,0.0006417016,0.003733412,0.0005313866,0.0003188648,0.0004064318,0.0003262158,0.0001421962,0.0008199615],"genre_scores_gemma":[0.9886862,0.00001574986,0.001029034,0.0007710432,0.00008395133,0.00004159442,0.0001477631,0.0000198868,0.009204769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008384807,"threshold_uncertainty_score":0.9999797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444461152407203,"score_gpt":0.2634255858648696,"score_spread":0.2389809743407976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}