{"id":"W2019628879","doi":"10.1186/1471-2091-10-9","title":"alpha-Sarcin catalytic activity is not required for cytotoxicity","year":2009,"lang":"en","type":"article","venue":"BMC Biochemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC","keywords":"Ribosome; Ricin; Protein biosynthesis; Biology; Cytoplasm; Ribosomal RNA; Mutant; Ribosome-inactivating protein; Cytotoxicity; Biochemistry; Cell biology; Programmed cell death; Ribosomal protein; RNA; Toxin; In vitro; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654122,0.0004584392,0.0003329564,0.0002044048,0.0001379382,0.0004095261,0.0004437702,0.0004349136,0.001937925],"category_scores_gemma":[0.0002864911,0.0001424577,0.0002638869,0.0001485298,0.0003842267,0.0001919971,0.0002687438,0.0004875996,0.0008521443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003591318,"about_ca_system_score_gemma":0.000276914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000362286,"about_ca_topic_score_gemma":0.0004484562,"domain_scores_codex":[0.9996244,0.00004883203,0.00006278558,0.00007044573,0.0001327478,0.00006078624],"domain_scores_gemma":[0.999233,0.0001623949,0.0002722571,0.0001367919,0.00006543006,0.0001300606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006550246,0.00002814562,0.0002924118,0.00002826825,0.000004152492,0.0001237818,0.00000531795,0.00003219681,0.9990392,0.00005983893,0.00002210595,0.0002990526],"study_design_scores_gemma":[0.00001252256,0.0001259683,0.00684898,0.000008992537,0.00001465056,0.0008841482,0.00002107913,0.0006363351,0.9900444,0.00003710719,0.001361894,0.000003979428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934769,0.001223076,0.002376112,0.0001133087,0.00004879877,0.00002811663,0.0005896226,0.0001385159,0.002005489],"genre_scores_gemma":[0.9961856,0.0002714827,0.0009347552,0.00003739966,0.000008555157,0.00002039471,0.0008789277,0.00004132728,0.001621478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937925,"threshold_uncertainty_score":0.006483018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444461152407203,"score_gpt":0.2634255858648696,"score_spread":0.2389809743407976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}