{"id":"W2019641286","doi":"10.1186/cc9382","title":"Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)","year":2010,"lang":"en","type":"article","venue":"Critical Care","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Krell Institute; Kuopion Yliopistollinen Sairaala; Universitair Ziekenhuis Gent; Imperial College Healthcare NHS Trust; Imperial College London; Loma Linda University; London Health Sciences Centre; University of Louisville; Eli Lilly and Company; Cliniques Universitaires Saint-Luc; Tays; U.S. Department of Veterans Affairs","keywords":"Medicine; Drotrecogin alfa; Sepsis; Randomized controlled trial; Internal medicine; Protein C; Clinical endpoint; Gastroenterology; Severe sepsis; Septic shock","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003616875,0.0002499245,0.0009620023,0.0001169887,0.00005993532,0.00002883358,0.00007176573,0.0002041542,0.001027868],"category_scores_gemma":[0.003901615,0.0001685676,0.0001532795,0.0002725492,0.0001785228,0.0001052451,0.00003167772,0.0002959982,0.000007394942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000105269,"about_ca_system_score_gemma":0.0002234388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000475905,"about_ca_topic_score_gemma":0.00006828349,"domain_scores_codex":[0.9980099,0.0002783451,0.0005300524,0.0003862198,0.0004628296,0.0003326987],"domain_scores_gemma":[0.9979659,0.0008629979,0.00008935297,0.0002949744,0.0006211579,0.0001656533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9276439,0.002884502,0.04799439,0.0005206795,0.000278362,0.00005237806,0.0008867921,0.000007117029,0.01427436,0.0007466024,0.00005367694,0.004657275],"study_design_scores_gemma":[0.9176023,0.003357767,0.006021217,0.0006104831,0.0006396368,0.000005195237,0.0004079342,0.00006275062,0.07079153,0.0002513913,0.00002158556,0.0002282096],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939592,0.00005294265,0.000005202363,0.0002170171,0.0001921806,0.003633365,0.0001012076,0.00003994777,0.001798954],"genre_scores_gemma":[0.9956671,9.073491e-7,0.002954322,0.00007420573,0.0001254143,0.0009576402,0.0001420266,0.00003413081,0.00004427459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05651717,"threshold_uncertainty_score":0.9998853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08381706551968934,"score_gpt":0.377210061775571,"score_spread":0.2933929962558817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}