{"id":"W2019665981","doi":"10.1089/hum.2012.018","title":"Sustained Reduction of Hyperbilirubinemia in Gunn Rats After Adeno-Associated Virus-Mediated Gene Transfer of Bilirubin UDP-Glucuronosyltransferase Isozyme 1A1 to Skeletal Muscle","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Fondazione Telethon","keywords":"Bilirubin; Internal medicine; Glucuronosyltransferase; Endocrinology; Isozyme; Genetic enhancement; Skeletal muscle; Unconjugated hyperbilirubinemia; Chemistry; Medicine; Enzyme; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003820897,0.0009842761,0.0008323602,0.0006816504,0.0002047768,0.0003838982,0.000439248,0.0006656719,0.001113146],"category_scores_gemma":[0.0002770131,0.0002769222,0.0006328057,0.0002287744,0.0005897566,0.0005036027,0.0003050222,0.001144519,0.0003300331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004232349,"about_ca_system_score_gemma":0.0004329921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242995,"about_ca_topic_score_gemma":0.001724429,"domain_scores_codex":[0.9996797,0.00004142582,0.00003071562,0.00009072824,0.00007777215,0.00007955878],"domain_scores_gemma":[0.9994377,0.00003285483,0.0002170442,0.00005379081,0.0000553368,0.0002032576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004168463,0.0001691559,0.0001908768,0.00004233998,0.00001615386,0.00008143875,0.00003234082,0.00006448593,0.997236,0.00005673101,0.0000331493,0.001660516],"study_design_scores_gemma":[0.00009343328,0.006772204,0.003958565,0.00001416261,0.00007785379,0.0003613826,0.000069171,0.0008275161,0.9866952,0.00005564846,0.001059027,0.00001597639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950924,0.001362371,0.002277919,0.0001162187,0.00006411431,0.00004335048,0.0001661336,0.0002281756,0.0006494635],"genre_scores_gemma":[0.9895512,0.001586046,0.003521633,0.0001241557,0.00002484704,0.0001286456,0.0005155846,0.0000606659,0.004487071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242995,"threshold_uncertainty_score":0.00372386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773132379216306,"score_gpt":0.2808008564649088,"score_spread":0.2630695326727457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}