{"id":"W2019689022","doi":"10.1016/j.cbi.2011.02.027","title":"Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde","year":2011,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Glycolaldehyde; Glyceraldehyde; Glyoxal; Chemistry; Protein Carbonylation; Autoxidation; Biochemistry; Cytotoxicity; Glutathione; Organic chemistry; Dehydrogenase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840152,0.0002289926,0.0003580924,0.0001067559,0.0002111154,0.00002744887,0.00005616674,0.0002378607,0.0004578838],"category_scores_gemma":[0.0002734466,0.0001699993,0.00008517761,0.0001215309,0.0001178434,0.0001579435,0.00004982499,0.0003314237,0.00002221153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008121342,"about_ca_system_score_gemma":0.00003313807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004903295,"about_ca_topic_score_gemma":0.000006445107,"domain_scores_codex":[0.9987677,0.00005140714,0.0003316374,0.0004648304,0.00008611554,0.0002982914],"domain_scores_gemma":[0.9991868,0.0001478974,0.0001457552,0.0001792913,0.00009259482,0.000247721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000880855,0.000170052,0.0001180018,0.00008418185,0.00006083264,0.000006224562,0.0001253805,1.332227e-7,0.9943162,0.0017739,0.0005356226,0.001928569],"study_design_scores_gemma":[0.002580293,0.0008250732,0.004733874,0.0001031483,0.0001903514,0.000437865,0.0001183275,0.001251398,0.9711365,0.003639569,0.0146557,0.0003279184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707491,0.0003269794,0.02586604,0.0006858697,0.000189809,0.001447752,0.00004004899,0.0002068099,0.0004876285],"genre_scores_gemma":[0.9899672,0.0002578612,0.006691487,0.001743571,0.00007145385,0.000604492,0.0001193833,0.00002395257,0.0005205788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02317976,"threshold_uncertainty_score":0.6932371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1262035145875974,"score_gpt":0.3594312478520308,"score_spread":0.2332277332644335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}