{"id":"W2019689527","doi":"10.1371/journal.pbio.1000439","title":"Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases","year":2010,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Basic Energy Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Office of Science; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; U.S. Department of Energy","keywords":"Cyclophilin; Isomerase; Peptidylprolyl isomerase; Prolyl isomerase; Cis-trans-Isomerases; Cyclophilin A; Biology; Gene isoform; Biochemistry; Enzyme; PIN1; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005145563,0.00009739181,0.0001346868,0.00001958057,0.00003869945,0.000002707513,0.0001972882,0.0001740334,0.00001531961],"category_scores_gemma":[0.0001367634,0.00007032676,0.00005415292,0.00004727218,0.0004031829,0.000001632377,0.0001424252,0.00009034637,4.069234e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001613991,"about_ca_system_score_gemma":0.00002876345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005956163,"about_ca_topic_score_gemma":0.000002033705,"domain_scores_codex":[0.999391,0.00004483026,0.0001950028,0.0002091275,0.00004944675,0.0001106488],"domain_scores_gemma":[0.9994496,0.00001273522,0.000135637,0.0002959401,0.00007056675,0.00003549993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002526791,0.00003207001,0.06416968,0.00002223772,0.00002632913,1.058375e-7,0.00001914127,2.079117e-7,0.9353259,0.0002442254,0.00001216335,0.000122645],"study_design_scores_gemma":[0.0002231586,0.00008322915,0.07937441,0.000008439374,0.0000174281,0.000002731211,0.000006155881,0.00001266027,0.9198445,0.0002747804,0.00008073962,0.0000717428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994124,0.0001033818,0.000006474464,0.00004649517,0.00011002,0.000125862,0.0001413013,0.000005564022,0.00004850958],"genre_scores_gemma":[0.9994416,0.00001138118,0.00008757311,0.0000877959,0.0001364639,0.000008049895,0.0002041431,0.00001002439,0.00001296059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154814,"threshold_uncertainty_score":0.2867842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226262545906164,"score_gpt":0.2441151649004988,"score_spread":0.2318525394414372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}