{"id":"W2019689527","doi":"10.1371/journal.pbio.1000439","title":"Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases","year":2010,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Basic Energy Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Office of Science; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; U.S. Department of Energy","keywords":"Cyclophilin; Isomerase; Peptidylprolyl isomerase; Prolyl isomerase; Cis-trans-Isomerases; Cyclophilin A; Biology; Gene isoform; Biochemistry; Enzyme; PIN1; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009192084,0.0002562501,0.0001853568,0.0001901329,0.00009597383,0.0001886481,0.0001548096,0.0001434175,0.0005257645],"category_scores_gemma":[0.0001498043,0.00009403626,0.000220972,0.0002256049,0.0001031436,0.0001024395,0.00009427068,0.0002143142,0.000188091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685325,"about_ca_system_score_gemma":0.0002650637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001422186,"about_ca_topic_score_gemma":0.001436793,"domain_scores_codex":[0.9999449,0.0000099555,0.000004714878,0.00001258196,0.00001678419,0.00001095983],"domain_scores_gemma":[0.9999194,0.00001230587,0.0000196018,0.00001016395,0.00001244412,0.00002613385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002833497,0.0000413764,0.003522407,0.00006314529,0.00002140288,0.0002846104,0.00003460103,0.001081514,0.989193,0.0001993006,0.0001201993,0.005154995],"study_design_scores_gemma":[0.00005907217,0.0006160799,0.07896455,0.00002048411,0.00008500204,0.002169636,0.0001091328,0.008735677,0.8986325,0.0002923976,0.01029484,0.00002078076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962605,0.001281431,0.0009339322,0.00006078029,0.000004914087,0.00001177498,0.0006981679,0.00001444438,0.000734218],"genre_scores_gemma":[0.9901068,0.001204014,0.004052807,0.00005899197,0.0000106552,0.00001229387,0.003674252,0.000009816021,0.0008704214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422186,"threshold_uncertainty_score":0.002827764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226262545906164,"score_gpt":0.2441151649004988,"score_spread":0.2318525394414372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}