{"id":"W2019711560","doi":"10.1007/s10637-006-9002-y","title":"A phase II, open label, monotherapy study of liposomal doxorubicin in patients with metastatic malignant melanoma","year":2006,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"TransCanada (Canada); Royal Victoria Hospital; BC Cancer Agency; CancerCare Manitoba; University of Alberta","funders":"National Cancer Institute","keywords":"Medicine; Tolerability; Nausea; Vomiting; Chemotherapy; Doxorubicin; Melanoma; Internal medicine; Phases of clinical research; Oncology; Gastroenterology; Surgery; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001387104,0.001639937,0.002824534,0.0005238758,0.0005460095,0.0009149235,0.0006993285,0.001367582,0.003173476],"category_scores_gemma":[0.000814834,0.0007721555,0.001288437,0.0004100998,0.001201253,0.001198312,0.0003422835,0.003322156,0.0009822404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008735491,"about_ca_system_score_gemma":0.001209961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298429,"about_ca_topic_score_gemma":0.003402483,"domain_scores_codex":[0.999622,0.00015928,0.00001426812,0.00007515737,0.00003490246,0.00009430011],"domain_scores_gemma":[0.9993768,0.000126251,0.0000738904,0.00005115759,0.00003542312,0.0003365882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5842968,0.1389355,0.01314784,0.001358918,0.001475382,0.0009753959,0.001030545,0.003816004,0.1184122,0.0004819175,0.004871594,0.1311979],"study_design_scores_gemma":[0.41844,0.5607365,0.01135234,0.00003193161,0.0004177812,0.000405504,0.0001479394,0.001401846,0.004265896,0.000181078,0.002574847,0.00004433244],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944261,0.001332004,0.0005118571,0.0005544429,0.0001275146,0.001338882,0.0004809156,0.00004791184,0.001180235],"genre_scores_gemma":[0.98994,0.002225725,0.001370535,0.0007453821,0.0001861706,0.00157403,0.0009610151,0.0000334453,0.002963652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173476,"threshold_uncertainty_score":0.0106163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02426473383952529,"score_gpt":0.2733184239037009,"score_spread":0.2490536900641756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}