{"id":"W2019719669","doi":"10.1021/bi700951u","title":"TgCRND8 Amyloid Precursor Protein Transgenic Mice Exhibit an Altered γ-Secretase Processing and an Aggressive, Additive Amyloid Pathology Subject to Immunotherapeutic Modulation","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Hospital for Sick Children","keywords":"Amyloid precursor protein; Genetically modified mouse; Chemistry; Presenilin; Amyloid (mycology); Western blot; Blot; Alzheimer's disease; Molecular biology; Transgene; Pathology; Biochemistry; Biology; Medicine; Gene; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218421,0.0007052352,0.0004135092,0.0003997424,0.0001074822,0.0002838958,0.0002422603,0.0004012733,0.0007719164],"category_scores_gemma":[0.0001196568,0.0002042261,0.0002969296,0.0001410878,0.0002790321,0.0001852971,0.0001810944,0.0006649662,0.0002935679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783395,"about_ca_system_score_gemma":0.00009385404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002691751,"about_ca_topic_score_gemma":0.0003477633,"domain_scores_codex":[0.9998325,0.00001204862,0.00001934267,0.00005085697,0.0000467217,0.00003846611],"domain_scores_gemma":[0.9998832,0.00001183889,0.00004574293,0.00002092575,0.00001285362,0.00002538692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008424526,0.00002883532,0.00008728149,0.00001073568,0.000003182604,0.00007268998,0.000008455791,0.00002518633,0.9992198,0.00002427733,0.000009078683,0.0004262784],"study_design_scores_gemma":[0.00005801916,0.0009982083,0.006250552,0.00001094124,0.0000466382,0.001179953,0.00003589754,0.0007287971,0.9889236,0.00008216074,0.001675608,0.000009564059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974746,0.000357894,0.000998628,0.00004283829,0.00001575437,0.00002918958,0.0002441032,0.00009916611,0.0007377983],"genre_scores_gemma":[0.9939704,0.0005758798,0.002081302,0.00004193022,0.00001173989,0.00006865242,0.0004880605,0.00003017316,0.002731916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007719164,"threshold_uncertainty_score":0.002582312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194326328110421,"score_gpt":0.3223349948117982,"score_spread":0.300391731530694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}