{"id":"W2019719669","doi":"10.1021/bi700951u","title":"TgCRND8 Amyloid Precursor Protein Transgenic Mice Exhibit an Altered γ-Secretase Processing and an Aggressive, Additive Amyloid Pathology Subject to Immunotherapeutic Modulation","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Hospital for Sick Children","keywords":"Amyloid precursor protein; Genetically modified mouse; Chemistry; Presenilin; Amyloid (mycology); Western blot; Blot; Alzheimer's disease; Molecular biology; Transgene; Pathology; Biochemistry; Biology; Medicine; Gene; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002327212,0.0003035414,0.0002990972,0.0001098883,0.0001671818,0.00004995883,0.0001181409,0.0001994508,0.00009132388],"category_scores_gemma":[0.00005978042,0.0002789117,0.00007488287,0.0002190886,0.0001683639,0.0001888359,0.00002682244,0.0002116513,0.00001512829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001236763,"about_ca_system_score_gemma":0.0002786152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002860642,"about_ca_topic_score_gemma":0.00001733645,"domain_scores_codex":[0.9980506,0.00007584828,0.000297291,0.0006804036,0.0003352734,0.0005606248],"domain_scores_gemma":[0.9985379,0.00002783405,0.0001531978,0.0003895182,0.000189319,0.0007022285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003109356,0.0007534541,0.001871284,0.0002175631,0.0005294175,0.0002229574,0.0005951389,6.005457e-7,0.9446954,0.000001373448,0.00001441963,0.04798904],"study_design_scores_gemma":[0.002979681,0.00108595,0.03388988,0.0003503733,0.0002625746,0.0001845269,0.0003768495,0.0002384966,0.9602195,0.00004828785,0.00003651248,0.0003273531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930105,0.004968253,0.0002532074,0.00008156082,0.00002310601,0.001169306,0.0002166061,0.00009472088,0.0001827603],"genre_scores_gemma":[0.9970789,0.00005090937,0.00120592,0.0001220087,0.0002993006,0.0001583085,0.0009467033,0.00005413895,0.0000837955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04766169,"threshold_uncertainty_score":0.9999663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194326328110421,"score_gpt":0.3223349948117982,"score_spread":0.300391731530694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}