{"id":"W2019737732","doi":"10.1038/nature13386","title":"CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University and Génome Québec Innovation Centre","funders":"Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Wellcome Trust","keywords":"Biology; T-cell receptor; Immune system; Nucleotide salvage; Cytidine; T cell; DNA synthesis; Cell growth; Cell biology; Enzyme; Biochemistry; Nucleotide; DNA; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008822978,0.0006519588,0.0003514894,0.0007490388,0.0001685018,0.0003654226,0.0002804986,0.0005900231,0.001596675],"category_scores_gemma":[0.000324845,0.0002743592,0.0002084229,0.0003511956,0.0004727515,0.0001547775,0.0001900926,0.0006020092,0.0002487122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667615,"about_ca_system_score_gemma":0.0001383745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006660571,"about_ca_topic_score_gemma":0.00033463,"domain_scores_codex":[0.999926,0.00001467088,0.000006826459,0.00002794732,0.00001608339,0.000008487073],"domain_scores_gemma":[0.9998891,0.00004337555,0.00002917097,0.00001240843,0.000005400046,0.00002050241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003281385,0.00007473842,0.02538732,0.0001463861,0.00008549041,0.01034217,0.0001508426,0.0008725435,0.9345209,0.001225085,0.0005827882,0.02333044],"study_design_scores_gemma":[0.0002612224,0.001169168,0.2933863,0.0001060972,0.0004928781,0.08569732,0.0002914442,0.00769642,0.5955372,0.004708468,0.0105842,0.00006918392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928166,0.002233293,0.002976491,0.0001446589,0.00002609164,0.00001195914,0.0005517293,0.00007427105,0.001165004],"genre_scores_gemma":[0.9976535,0.0006795776,0.0008676865,0.00003791966,0.00002035973,0.00001449044,0.0002927834,0.00001701508,0.0004165715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596675,"threshold_uncertainty_score":0.00534147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00567151098746567,"score_gpt":0.2654162349081896,"score_spread":0.2597447239207239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}