{"id":"W2019737732","doi":"10.1038/nature13386","title":"CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University and Génome Québec Innovation Centre","funders":"Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Wellcome Trust","keywords":"Biology; T-cell receptor; Immune system; Nucleotide salvage; Cytidine; T cell; DNA synthesis; Cell growth; Cell biology; Enzyme; Biochemistry; Nucleotide; DNA; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002313859,0.000113855,0.000108533,0.00006131885,0.00003104433,0.00002031247,0.0001879636,0.0008922569,0.00001151642],"category_scores_gemma":[0.0002825619,0.0001038283,0.00004623488,0.000154102,0.0000279987,0.000003983318,0.00007570202,0.0005967517,0.000009465653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003963666,"about_ca_system_score_gemma":0.00006604747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001043233,"about_ca_topic_score_gemma":0.0001245088,"domain_scores_codex":[0.9988788,0.00009008717,0.000154731,0.0003439768,0.0001733645,0.0003590829],"domain_scores_gemma":[0.9996264,0.000006885568,0.00002739123,0.000212018,0.00005001238,0.00007726852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000840477,0.0001039491,0.006567989,0.00003178581,0.000002374284,0.000005524284,0.00003148622,0.00003765826,0.9908596,0.0004733784,0.0003942622,0.00140799],"study_design_scores_gemma":[0.000936512,0.0001171447,0.01583982,0.00003311835,0.000002897995,0.000005347555,0.00001590558,0.0003050009,0.9712355,0.0002547765,0.01106565,0.0001883631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935569,0.003421172,0.00006816759,0.0003050913,0.00005205176,0.0002182596,0.000007959502,0.000006826972,0.002363566],"genre_scores_gemma":[0.99856,0.0000775142,0.00009950664,0.0006496706,0.0001262117,0.00002694082,0.0001129757,0.00001286586,0.0003342917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01962409,"threshold_uncertainty_score":0.6881902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00567151098746567,"score_gpt":0.2654162349081896,"score_spread":0.2597447239207239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}