{"id":"W2019745301","doi":"10.1039/b714221h","title":"Synthesis and enzymatic stability of PEGylated oligonucleotide duplexes and their self-assemblies with polyamidoamine dendrimers","year":2007,"lang":"en","type":"article","venue":"Soft Matter","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Dendrimer; Phosphodiester bond; PEG ratio; Oligonucleotide; Nuclease; Chemistry; Ethylene glycol; Amidoamine; Conjugated system; Dispersity; Nucleic acid; Kinetics; Conjugate; Stereochemistry; Combinatorial chemistry; Polymer chemistry; Enzyme; Biochemistry; DNA; RNA; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544417,0.0001364478,0.0001601586,0.00004125035,0.00003473721,0.00001583167,0.00006917957,0.00006905961,0.00003905957],"category_scores_gemma":[0.00002047748,0.00009736592,0.00002782235,0.00004410894,0.0001197756,0.000006671179,0.00006079552,0.00004146933,0.000004467362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004590514,"about_ca_system_score_gemma":0.00001603983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004851685,"about_ca_topic_score_gemma":0.00008405369,"domain_scores_codex":[0.9993671,0.00002491412,0.0001650796,0.0002191228,0.00005414056,0.0001696991],"domain_scores_gemma":[0.9995779,0.00005446412,0.00006470588,0.0001966615,0.00005381033,0.00005239747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001207027,0.00003942319,0.1188815,0.00008848983,0.0001053583,0.000001593764,0.0003053621,4.725539e-7,0.8792307,0.000002844529,0.0002360361,0.0009874698],"study_design_scores_gemma":[0.0001546188,0.0001542248,0.08923567,0.00002872293,0.00002780479,0.00002289663,0.0005640276,0.00001438022,0.9095055,0.00001355695,0.0001550139,0.0001235314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986221,0.0005289637,0.0003532073,0.00009997735,0.00001728083,0.00008989279,0.00001330583,0.00001034925,0.0002648995],"genre_scores_gemma":[0.9992532,0.00007097265,0.0003767519,0.0002014318,0.00002185131,0.000004357321,0.000007456016,0.00001418301,0.00004978005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03027481,"threshold_uncertainty_score":0.3970467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006081089361599493,"score_gpt":0.2067247621975552,"score_spread":0.2006436728359557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}