{"id":"W2019749372","doi":"10.1016/j.joca.2012.02.024","title":"F-spondin (spondin-1) null mice exhibit increased bone formation, decreased osteoclast function and accelerated osteoarthritis","year":2012,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Osteoarthritis; Thrombospondin; Conditional gene knockout; Knockout mouse; Medial meniscus; Western blot; Endocrinology; Internal medicine; Cartilage; In vivo; Chondrocyte; Osteoclast; Mutant; Chemistry; Pathology; Medicine; Molecular biology; Phenotype; Biology; Anatomy; Genetics; Receptor; Biochemistry; Metalloproteinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004058855,0.001743104,0.0008671903,0.002804245,0.0004599134,0.0008478432,0.0006593114,0.001518046,0.006498491],"category_scores_gemma":[0.0002894833,0.0008736577,0.0007888265,0.0007943783,0.001010357,0.0004961716,0.0005227851,0.002082612,0.001931934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004646401,"about_ca_system_score_gemma":0.0004392909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000934992,"about_ca_topic_score_gemma":0.002203981,"domain_scores_codex":[0.9992409,0.00007135845,0.0001225412,0.0001565275,0.0002826079,0.0001261174],"domain_scores_gemma":[0.9988198,0.00009339314,0.0006145992,0.00007111823,0.00006400704,0.0003370139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002364194,0.00004788407,0.0002302507,0.00003094129,0.00001358289,0.0002360812,0.00001687944,0.00005545524,0.998184,0.0001630967,0.00006585856,0.0007195297],"study_design_scores_gemma":[0.0002112472,0.0004546265,0.01133779,0.0000250133,0.0001151944,0.004102868,0.0001308034,0.001062686,0.9784733,0.0003102966,0.003739083,0.00003699372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98452,0.001992936,0.006716259,0.0003486365,0.0001130697,0.00004600778,0.003397824,0.0007322162,0.002133167],"genre_scores_gemma":[0.9640167,0.001941238,0.007741394,0.0002284524,0.00006784987,0.0001512527,0.002919585,0.000417486,0.02251606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006498491,"threshold_uncertainty_score":0.0217396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008761388491403526,"score_gpt":0.2178159429470761,"score_spread":0.2090545544556725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}