{"id":"W2019756575","doi":"10.1093/brain/awt372","title":"Nerve growth factor metabolic dysfunction in Down’s syndrome brains","year":2014,"lang":"en","type":"article","venue":"Brain","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health; Canadian Institutes of Health Research; Merck Canada; Alzheimer Society; Secretaría de Educación Pública; McGill University","keywords":"Basal forebrain; Nerve growth factor; Endocrinology; Internal medicine; Choline acetyltransferase; Cholinergic neuron; Down syndrome; Biology; Cerebral cortex; Cholinergic; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007462715,0.0003833448,0.0002534865,0.0009915333,0.0001928261,0.0001973107,0.0001058366,0.0001968109,0.001133295],"category_scores_gemma":[0.0001308193,0.0002002787,0.0001539744,0.0002676499,0.0002496571,0.000143775,0.0001586707,0.0002567625,0.0001371798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001380794,"about_ca_system_score_gemma":0.0001217739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350691,"about_ca_topic_score_gemma":0.001583282,"domain_scores_codex":[0.9999416,0.000006186385,0.000008233514,0.00001911746,0.00001458484,0.00001037774],"domain_scores_gemma":[0.9999228,0.00001043049,0.0000289241,0.00000449242,0.00001192762,0.00002144072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005994559,0.0000314854,0.02463478,0.00010578,0.00004549625,0.002787411,0.0002388027,0.00003363146,0.9683245,0.00004753116,0.00004965348,0.003101481],"study_design_scores_gemma":[0.00003138302,0.0006504317,0.8501837,0.00003164681,0.000131386,0.01329163,0.000545317,0.0003444129,0.1332379,0.0001450638,0.001389246,0.00001785661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998312,0.0008411553,0.0002618169,0.0000132932,0.000004121503,0.000007570945,0.0002055593,0.00000991703,0.0003445608],"genre_scores_gemma":[0.9973453,0.001051784,0.0005216294,0.00001717318,0.000005433038,0.0000230366,0.0003894414,0.000006358192,0.0006398464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350691,"threshold_uncertainty_score":0.003791213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0312150739972934,"score_gpt":0.299764018297933,"score_spread":0.2685489443006396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}