{"id":"W2019763279","doi":"10.1016/j.bmc.2015.04.064","title":"Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Drug Research and Development; Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Peptide; Förster resonance energy transfer; Enzyme; Substrate (aquarium); Protease; Cleavage (geology); Cysteine; Biochemistry; Combinatorial chemistry; Cysteine protease; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006014821,0.0002359137,0.0003601788,0.00002372277,0.0001210849,0.00001279637,0.0001575516,0.0001214996,0.0001102891],"category_scores_gemma":[0.0004532481,0.0001575129,0.00007041632,0.000128852,0.0001810787,0.00003965596,0.00005427015,0.000190882,0.000005339327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001019985,"about_ca_system_score_gemma":0.0008988551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001214886,"about_ca_topic_score_gemma":0.000001463855,"domain_scores_codex":[0.9984283,0.00001709564,0.000494587,0.0002899434,0.0004688292,0.0003012523],"domain_scores_gemma":[0.998732,0.000131264,0.0002150926,0.0003102605,0.0002325778,0.0003788405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005915949,0.0002448297,0.001292713,0.001024832,0.0002961948,0.0000576625,0.002384912,5.020647e-7,0.9883092,0.00004130068,0.00119497,0.00456127],"study_design_scores_gemma":[0.003462219,0.0001711675,0.003853019,0.0003780133,0.0002323041,0.0001271574,0.002246507,0.0002656188,0.985663,0.00005681547,0.003378944,0.0001652253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905357,0.006900314,0.0004383559,0.0006411317,0.0000880995,0.0007091143,0.00001805897,0.000064868,0.0006043182],"genre_scores_gemma":[0.9960515,0.00005118019,0.00265148,0.0002375101,0.0004848815,0.00009160846,0.00006321383,0.00003373886,0.0003349265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006849134,"threshold_uncertainty_score":0.6423188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04296820150825718,"score_gpt":0.2843415087248843,"score_spread":0.2413733072166271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}