{"id":"W2019781558","doi":"10.1016/j.gene.2008.05.009","title":"DNA demethylation induced by the methyl-CpG-binding domain protein MBD3","year":2008,"lang":"en","type":"article","venue":"Gene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Biology; DNA demethylation; Promoter; Methylated DNA immunoprecipitation; Methylation; Molecular biology; Epigenetics of physical exercise; CpG site; Demethylation; Repressor; Epigenomics; DNA binding site; Bisulfite sequencing; Genetics; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004453894,0.000154811,0.0001147272,0.00003629057,0.0002934686,0.00002042568,0.0001889692,0.0001822894,0.00003171205],"category_scores_gemma":[0.00008625905,0.000123202,0.00007854578,0.0001478853,0.00005722814,0.00000438168,0.00007957924,0.0001083664,0.00002585006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001932078,"about_ca_system_score_gemma":0.00005794301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002860205,"about_ca_topic_score_gemma":0.00001289291,"domain_scores_codex":[0.9988427,0.0001625193,0.000228501,0.0003154455,0.0002014182,0.0002494856],"domain_scores_gemma":[0.9993523,0.00001560234,0.0001162634,0.0003770998,0.0000702146,0.00006849453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001869324,0.00002297397,0.000396192,0.00000301,0.00002809011,0.000001047899,0.00008141321,0.00001697259,0.9951744,0.00004543511,0.0003837585,0.003827991],"study_design_scores_gemma":[0.0003264614,0.000133286,0.001215412,0.000003072481,0.000009207102,0.000004154134,0.00002948886,0.00002230332,0.9725487,0.0004986721,0.02504351,0.0001656805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888162,0.001750932,0.007781857,0.0002908102,0.0001174571,0.0003569956,0.00001597258,0.00001560233,0.000854172],"genre_scores_gemma":[0.9959604,0.0001509957,0.002452687,0.00009768149,0.0002698639,0.00008984538,0.0001953633,0.00002785217,0.0007553661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02465975,"threshold_uncertainty_score":0.5024031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112684128459844,"score_gpt":0.2513310348602687,"score_spread":0.2302041935756703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}