{"id":"W2019785713","doi":"10.6000/1929-5634.2015.04.01.6","title":"Methylmalonic Acidemia: Can Treatment be Improved?","year":2015,"lang":"en","type":"article","venue":"Journal of Nutritional Therapeutics","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario","funders":"","keywords":"Methylmalonic acidemia; Mutase; Methylmalonic acid; Internal medicine; Endocrinology; Propionic acidemia; Medicine; Gastroenterology; Vitamin B12; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000810765,0.0007045644,0.001932364,0.0006960048,0.0006283488,0.001083073,0.0008135674,0.003030296,0.009319711],"category_scores_gemma":[0.002943154,0.0001408047,0.001203786,0.0004019007,0.0005629312,0.001915272,0.0005192175,0.004659637,0.002785702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005674306,"about_ca_system_score_gemma":0.001190338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398563,"about_ca_topic_score_gemma":0.002881469,"domain_scores_codex":[0.9996312,0.0001057809,0.00005169258,0.00005364475,0.00007973288,0.00007797654],"domain_scores_gemma":[0.9992753,0.0002047688,0.00008297327,0.00003219437,0.0001993014,0.0002054276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003625669,0.001682281,0.003854827,0.004862736,0.000705511,0.004387598,0.0001255294,0.0007387204,0.003378179,0.008764301,0.1715514,0.7963233],"study_design_scores_gemma":[0.004297,0.003109348,0.02058895,0.02301499,0.001646047,0.01363667,0.001635711,0.001639244,0.0024403,0.06710275,0.8606083,0.0002806854],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01326086,0.6458457,0.0046909,0.2993064,0.0142227,0.0001827631,0.0006160242,0.0005085364,0.0213662],"genre_scores_gemma":[0.1322235,0.6739568,0.01397926,0.1363962,0.0249028,0.0005642357,0.001639274,0.0001306816,0.01620718],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009319711,"threshold_uncertainty_score":0.03117758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06179143708666453,"score_gpt":0.3172072473261865,"score_spread":0.255415810239522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}