{"id":"W2019802394","doi":"10.1002/art.10055","title":"Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator‐activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: Evidence for receptor antagonism","year":2002,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute for Materials Science","keywords":"Transactivation; Molecular biology; Peroxisome proliferator-activated receptor; Reporter gene; Chemistry; Agonist; Response element; Electrophoretic mobility shift assay; Transfection; Receptor; Gene expression; Biology; Promoter; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004045988,0.0006733264,0.0007780193,0.000361935,0.0003513629,0.0001120497,0.0004943444,0.0007366839,0.0005117079],"category_scores_gemma":[0.0007292071,0.0007082614,0.0002712389,0.0004374753,0.0002764445,0.0002019442,0.0002660966,0.0004376652,0.00002905833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000135055,"about_ca_system_score_gemma":0.0001438524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001113148,"about_ca_topic_score_gemma":0.00006541187,"domain_scores_codex":[0.9955588,0.0004245973,0.001362689,0.001265304,0.0005330519,0.0008555605],"domain_scores_gemma":[0.997828,0.0001031392,0.0006226404,0.0008066545,0.0003271274,0.000312412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006815924,0.0006907235,0.00084106,0.0001829003,0.0001013966,0.000002966408,0.0005440859,0.0000820921,0.9831961,0.0000208674,0.007653793,0.00600246],"study_design_scores_gemma":[0.00429305,0.00130574,0.0002781498,0.001836289,0.00001664301,0.00003383901,0.0001284093,0.00005628751,0.9891364,0.00005643476,0.002117056,0.0007416748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902151,0.005938932,0.0003606235,0.0001377667,0.0009768923,0.00173541,0.0005043832,0.0001007861,0.0000301683],"genre_scores_gemma":[0.9874681,0.006896311,0.003114172,0.00004945329,0.0006241179,0.0007721776,0.00078419,0.0001446527,0.0001468808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005940364,"threshold_uncertainty_score":0.9995369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02450432084993478,"score_gpt":0.2660054703312387,"score_spread":0.2415011494813039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}