{"id":"W2019818770","doi":"10.1021/jm8004702","title":"Novel Opioid Peptide Derived Antagonists Containing (2<i>S</i>)-2-Methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic Acid [(2<i>S</i>)-Mdcp]","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Propanoic acid; Antagonist; Stereochemistry; Chemical synthesis; Cyclic peptide; Selectivity; Opioid; Peptide; Agonist; Opioid peptide; Receptor; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001111429,0.0004184713,0.000648165,0.0001132858,0.0001184858,0.0002502555,0.0004806797,0.0003035603,0.0009617534],"category_scores_gemma":[0.0001265799,0.0002036393,0.0001868934,0.0001491592,0.0001679662,0.0002332312,0.0002102769,0.0006869334,0.000558952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634188,"about_ca_system_score_gemma":0.0003032095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003637121,"about_ca_topic_score_gemma":0.001293738,"domain_scores_codex":[0.9999192,0.000009837723,0.000006089432,0.00001380945,0.00002026138,0.00003079175],"domain_scores_gemma":[0.9999409,0.000007309359,0.0000187309,0.000003669111,0.000007565319,0.00002190209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002195516,0.00004843942,0.00009655531,0.00006471231,0.00001075611,0.0001045223,0.00001615307,0.0001670267,0.9946825,0.0001390499,0.00008823447,0.004362424],"study_design_scores_gemma":[0.0003975072,0.00454389,0.00307606,0.0000178852,0.00008605995,0.0009775005,0.00003266427,0.001712291,0.978555,0.000101733,0.01046701,0.00003238647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828562,0.005625635,0.006665941,0.0001025897,0.00008861971,0.0002554581,0.0004919039,0.0001515475,0.003762058],"genre_scores_gemma":[0.9778985,0.004125367,0.01246474,0.0002068111,0.00008587633,0.0002629089,0.001142408,0.00003091276,0.003782364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009617534,"threshold_uncertainty_score":0.003217399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746899637896858,"score_gpt":0.2627743692450662,"score_spread":0.2253053728660976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}