{"id":"W2019887943","doi":"10.1186/1471-2407-9-165","title":"Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situhybridization (FISH): pathologist assessment compared to quantitative image analysis","year":2009,"lang":"en","type":"article","venue":"BMC Cancer","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Centre for Advancing Health Outcomes; University of British Columbia","funders":"Canadian Institutes of Health Research; Sanofi","keywords":"Kappa; Concordance; Medicine; Immunohistochemistry; Fish <Actinopterygii>; Pathology; Breast cancer; Cohen's kappa; Internal medicine; Tissue microarray; Reproducibility; Surgical oncology; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001373641,0.0002003264,0.0007423527,0.0002240603,0.00003745766,0.00002872642,0.0001486801,0.00005441933,0.0001343897],"category_scores_gemma":[0.000266995,0.0001688192,0.00008829415,0.001120731,0.0002532912,0.0000991697,0.00008654666,0.0003099254,0.000001147346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001569713,"about_ca_system_score_gemma":0.000740191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0023819,"about_ca_topic_score_gemma":0.003646411,"domain_scores_codex":[0.9972435,0.0002217588,0.0005890869,0.001090869,0.0005465297,0.0003082069],"domain_scores_gemma":[0.9979316,0.00009937402,0.0001886356,0.001138805,0.0004895585,0.0001520069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001362095,0.0005470321,0.9227686,0.0002335049,0.0001470142,0.00003485045,0.0004933393,0.0005716107,0.0708197,0.00008014438,0.0007716012,0.002170519],"study_design_scores_gemma":[0.001570559,0.0008013285,0.9790735,0.0003664156,0.0001856533,0.000004205072,0.0003475765,0.003786998,0.0135349,0.00002403146,0.0001291218,0.0001757302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823171,0.000399666,0.0138537,0.001768727,0.00004810174,0.001148115,0.00006893412,0.000027614,0.0003680133],"genre_scores_gemma":[0.9593565,0.0001216096,0.03990197,0.000293206,0.00002946464,0.0001630058,0.0000615409,0.00001533573,0.00005741229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0572848,"threshold_uncertainty_score":0.6884248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06874392968058383,"score_gpt":0.4566391556024249,"score_spread":0.3878952259218411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}