{"id":"W2019892034","doi":"10.1371/journal.ppat.1002718","title":"Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University Health Network; Mount Sinai Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Burroughs Wellcome Fund; University of Toronto; Center for AIDS Research, University of Washington; Center for AIDS Research, Duke University; National Institutes of Health","keywords":"Echinocandin; Echinocandins; Caspofungin; Candida glabrata; Biology; Drug resistance; Calcineurin; Antifungal drug; Microbiology; Resistance mutation; Candida albicans; Genetics; Fluconazole; Medicine; Gene; Antifungal; Transplantation; Polymerase chain reaction; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009972898,0.0002910108,0.0002610619,0.0004736601,0.0001496514,0.000262481,0.0002004849,0.0003000217,0.0005279782],"category_scores_gemma":[0.0001427846,0.00009955576,0.0003061196,0.0005360474,0.0001410522,0.0001230698,0.0002414344,0.0003711412,0.0001117929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002697213,"about_ca_system_score_gemma":0.0001077985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001508615,"about_ca_topic_score_gemma":0.001566194,"domain_scores_codex":[0.9999191,0.000008209148,0.000006550324,0.00002806315,0.00001961052,0.00001844508],"domain_scores_gemma":[0.9999198,0.00001296994,0.00002568799,0.00001070339,0.00001533068,0.00001547417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001698479,0.00002770265,0.004643318,0.00004076046,0.00002961747,0.0001004163,0.00002785553,0.0007225379,0.9899975,0.00007568151,0.000054497,0.004110316],"study_design_scores_gemma":[0.0000563381,0.001324717,0.4404331,0.00002474857,0.0001838983,0.002683329,0.0003022516,0.00931067,0.5401267,0.000423999,0.005085994,0.00004417661],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968321,0.0004080609,0.001033686,0.00004008593,0.000003465109,0.00002073098,0.001056825,0.00005492705,0.0005502005],"genre_scores_gemma":[0.9964358,0.0002479746,0.001269658,0.00004237255,0.000002275738,0.00001926487,0.001351223,0.00002255718,0.0006090534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508615,"threshold_uncertainty_score":0.002999604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545181970355643,"score_gpt":0.2578491721928496,"score_spread":0.2423973524892932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}