{"id":"W2019904028","doi":"10.1159/000126966","title":"Alpha-2-Adrenergic Activation of Proopiomelanocortin-Containing Neurons in the Arcuate Nucleus Causes Opioid-Mediated Hypotension and Bradycardia","year":2008,"lang":"en","type":"article","venue":"Neuroendocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Endocrinology; Internal medicine; Arcuate nucleus; Proopiomelanocortin; Yohimbine; Hypothalamus; Nociceptin receptor; Chemistry; Nucleus; Opioid peptide; Opioid; Receptor; Biology; Medicine; Antagonist; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002479521,0.0001566628,0.0002503625,0.0002293835,0.0001715532,0.00001332826,0.0002214721,0.00004099257,0.00001010907],"category_scores_gemma":[0.0005512393,0.0001235891,0.00004771792,0.0003891071,0.0003117392,0.0001660833,0.0001025093,0.0002472606,0.00001141421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001136956,"about_ca_system_score_gemma":0.00004091605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008426689,"about_ca_topic_score_gemma":0.00001549609,"domain_scores_codex":[0.998352,0.000344645,0.0003317554,0.0004089696,0.0002228731,0.0003397799],"domain_scores_gemma":[0.9988527,0.0005893465,0.0001811302,0.0002955286,0.00003648381,0.00004486521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002174676,0.0001595369,0.09723371,0.00002509237,0.000005076048,0.0008669457,0.0008527217,0.0002778914,0.8941935,0.002740509,0.0001834813,0.003244028],"study_design_scores_gemma":[0.0006891463,0.0002998765,0.7625567,0.0000103956,0.000006593395,0.0008027985,0.00004405729,0.0004603866,0.2319317,0.0002352515,0.002859803,0.000103256],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976308,0.00003721211,0.000008197666,0.001178149,0.0001440461,0.0003165152,0.000005334246,0.00005478159,0.0006249815],"genre_scores_gemma":[0.9974456,0.001030547,0.00002671464,0.001375466,0.00003928309,0.00001754375,0.000004688506,0.00001625065,0.0000439043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.665323,"threshold_uncertainty_score":0.5039818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0402285897062914,"score_gpt":0.2562365088531972,"score_spread":0.2160079191469058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}