{"id":"W2019904028","doi":"10.1159/000126966","title":"Alpha-2-Adrenergic Activation of Proopiomelanocortin-Containing Neurons in the Arcuate Nucleus Causes Opioid-Mediated Hypotension and Bradycardia","year":2008,"lang":"en","type":"article","venue":"Neuroendocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Endocrinology; Internal medicine; Arcuate nucleus; Proopiomelanocortin; Yohimbine; Hypothalamus; Nociceptin receptor; Chemistry; Nucleus; Opioid peptide; Opioid; Receptor; Biology; Medicine; Antagonist; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162848,0.0005707562,0.0004302867,0.0004338928,0.0002108368,0.0002023057,0.0002816128,0.0003011835,0.00149511],"category_scores_gemma":[0.0001426285,0.0002868503,0.0003528412,0.0001883506,0.0003899688,0.000202597,0.0002020073,0.001044443,0.0003272634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003903193,"about_ca_system_score_gemma":0.0003006456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069962,"about_ca_topic_score_gemma":0.0025626,"domain_scores_codex":[0.999814,0.00002324458,0.0000113057,0.00004059564,0.00004366622,0.00006724605],"domain_scores_gemma":[0.9997852,0.00002361279,0.00005909109,0.00002296733,0.00001265113,0.00009639279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006988008,0.00005993968,0.0004429775,0.0000183556,0.000008209923,0.00009293631,0.00001984519,0.00003447789,0.9978775,0.00002281306,0.00002578893,0.0006985606],"study_design_scores_gemma":[0.00008898976,0.003579681,0.02700634,0.00001049601,0.00003814856,0.0003982542,0.00008483118,0.0007666209,0.9672149,0.00005151596,0.0007483981,0.00001186746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982279,0.000350623,0.0005982216,0.00003817644,0.00002165931,0.00001768798,0.000165094,0.00005964778,0.0005210219],"genre_scores_gemma":[0.9936888,0.0006490177,0.002090922,0.00006415931,0.00002205409,0.0001110353,0.0004935855,0.000026542,0.002854038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149511,"threshold_uncertainty_score":0.005001664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0402285897062914,"score_gpt":0.2562365088531972,"score_spread":0.2160079191469058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}