{"id":"W2019905182","doi":"10.1038/ng.2007.28","title":"RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression","year":2007,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of Miami","keywords":"Myotonic dystrophy; Biology; Transgene; RNA; Muscular dystrophy; Gene expression; Toxicity; Messenger RNA; Gene silencing; Duchenne muscular dystrophy; Myopathy; Connexin; Myotonia; Cell biology; Small interfering RNA; RNA interference; Molecular biology; Gene; Genetics; Internal medicine; Medicine; Gap junction; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002232564,0.0002725905,0.0002102878,0.0002250729,0.0001210105,0.00005258209,0.0005316545,0.0003576891,0.00004939422],"category_scores_gemma":[0.0005538971,0.0002500846,0.00009733775,0.0005983554,0.0001196203,0.00006679039,0.0001832625,0.0007787502,0.00003275429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006409276,"about_ca_system_score_gemma":0.00007899317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002632744,"about_ca_topic_score_gemma":0.00001879727,"domain_scores_codex":[0.9975378,0.0001785481,0.0003380366,0.000742273,0.0006464765,0.0005568776],"domain_scores_gemma":[0.9989206,0.0001491958,0.0001110704,0.0005514961,0.0000667731,0.0002008826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003456088,0.0001421211,0.001907761,0.00001346349,0.000001434057,0.00008410314,0.0001126125,0.0004983117,0.9948425,0.00006310979,0.0001640762,0.002135981],"study_design_scores_gemma":[0.0004047595,0.00009015206,0.06801716,0.00002248133,0.000007542587,0.000006108097,0.00003737906,0.00008482487,0.9296655,0.0003031657,0.001121374,0.0002395211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959978,0.001199332,0.0002672671,0.0000936155,0.0006951926,0.0003842491,0.00001951147,0.0000603178,0.001282713],"genre_scores_gemma":[0.9967531,0.000156512,0.001391767,0.001322472,0.0002192407,0.00001286213,0.00000367425,0.00003856315,0.0001018154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0661094,"threshold_uncertainty_score":0.9999951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694472193985111,"score_gpt":0.2852041998650161,"score_spread":0.2682594779251649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}