{"id":"W2019905182","doi":"10.1038/ng.2007.28","title":"RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression","year":2007,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of Miami","keywords":"Myotonic dystrophy; Biology; Transgene; RNA; Muscular dystrophy; Gene expression; Toxicity; Messenger RNA; Gene silencing; Duchenne muscular dystrophy; Myopathy; Connexin; Myotonia; Cell biology; Small interfering RNA; RNA interference; Molecular biology; Gene; Genetics; Internal medicine; Medicine; Gap junction; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002443132,0.0003802757,0.0003121646,0.0004275978,0.0003981134,0.0004055622,0.0002297105,0.000640563,0.003132512],"category_scores_gemma":[0.0002300722,0.000307492,0.0003906448,0.0001473394,0.0004446068,0.0002909426,0.000442528,0.0008020068,0.0006758702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000633002,"about_ca_system_score_gemma":0.0002389555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115735,"about_ca_topic_score_gemma":0.002669635,"domain_scores_codex":[0.9996244,0.00008161878,0.0000528873,0.00007894778,0.00009377337,0.00006835078],"domain_scores_gemma":[0.9998504,0.0000397515,0.00003640529,0.00001784524,0.00001194848,0.00004377514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008089226,0.00001469512,0.0001700737,0.00002577235,0.000007209607,0.0001908974,0.0000115512,0.00009002445,0.9987205,0.0001878833,0.00007943129,0.0004210245],"study_design_scores_gemma":[0.00002564396,0.0002050495,0.008901454,0.00001324521,0.00002745974,0.001115988,0.00006494171,0.001129099,0.9862621,0.0001562433,0.002092617,0.000006133293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874837,0.002525524,0.004204308,0.0004037993,0.0001600266,0.00003978453,0.0007091618,0.000129888,0.004343743],"genre_scores_gemma":[0.9914478,0.0005309568,0.001516987,0.0001715281,0.00001860281,0.00003566721,0.00077977,0.00004537567,0.005453417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003132512,"threshold_uncertainty_score":0.01047933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694472193985111,"score_gpt":0.2852041998650161,"score_spread":0.2682594779251649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}